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Table 3 Independent predictors of vasoplegia using previous definitions of vasoplegia and the unified definition

From: Vasoplegia after implantation of a continuous flow left ventricular assist device: incidence, outcomes and predictors

Argenziano   Univariable Multivariable
Preoperative characteristics No vasoplegia
n = 90
Vasoplegia
n = 28
P-value OR (95% CI) P-value OR (95% CI) P-value
Pre-op dobutamine 43 (47.8%) 19 (67.9%) 0.04 2.65 (1.05–6.68) 0.04 2.65 (1.05–6.68) 0.04
Pre-op VIS 4.3 [0.0–7.3] 6.5 [4.0–11.9] 0.03 1.03 (1.00–1.06) 0.05   
Neutrophil/
Lymphocyt –ratio
4.5 [3.6–7.7] 8.0 [5.6–9.5] 0.04 1.13 (1.00 1.28) 0.05   
Levin   Univariable Multivariable
Preoperative characteristics No vasoplegia
n = 115
Vasoplegia
n = 3
P-value OR (95% CI) P-value OR (95% CI) P-value
NCCMP 3 (2.6%) 2 (66.7%) <  0.01 74.67 (5.22–1067.12) <  0.01   1.00
DCMP 85 (73.9%) 0 (0.0%) <  0.01 0.0 (0.0-∞) 1.00   
Clopidogrel 6 (5.2%) 1 (33.3%) 0.04 9.08 (0.71–114.92) 0.09   
Insuline 4 (3.5%) 1 (33.3%) 0.01 13.88 (1.03–186.60) <  0.05   1.00
Preop norepinephrine 12 (10.4%) 3 (100%) <  0.01 17.17 (1.45–203.67) 0.02   1.00
Lactate 1.9 [1.4–2.7] 13.1 0.03 ∞ (0.00-∞) 0.98   
Patarroyo   Univariable Multivariable
Preoperative characteristics No vasoplegia
n = 109
Vasoplegia
n = 9
P-value OR (95% CI) P-value OR (95% CI) P-value
Previous CT-surgery 10 (9.2%) 4 (44.4%) <  0.01 7.92 (1.83–34.30) <  0.01 10.4 (2.04–53.08) <  0.01
Pre-op dopamine 22 (20.2%) 5 (55.5%) 0.02 4.94 (1.22–19.96) 0.03 6.46 (1.36–30.55) 0.02
Unified definition   Univariable Multivariable
Preoperative characteristics No vasoplegia
n = 79
Vasoplegia
n = 39
P-value OR (95% CI) P-value OR (95% CI) P-value
Previous CT-surgery 5 (6.3%) 9 (23.1%) <  0.01 4.44 (1.38–14.34) 0.01 7.60 (1.98–29.24) <  0.01
Euroscore II* 20.6 [15.3–25.1] 32.6 [20.6–42.2] <  0.01 1.06 (1.03–1.10) <  0.01   
Pre-op dopamine 13 (16.5%) 14 (35.9%) 0.02 2.84 (1.17–6.88) 0.02 3.83 (1.28–11.46) 0.02
Pre-op VIS 4.1 [0.0–6.7] 6.5 [4.0–10.6] <  0.01 1.04 (1.00–1.08) 0.06   
Bilirubin (μmol·l−1) 27.0 [15.5–37.3] 36.0 [25.0–44.5] <  0.01 1.04 (1.01–1.07) <  0.01 1.04 (1.01–2.08) <  0.01
Creatinine* (μmol·l−1) 101 [91–150] 157 [117–186] 0.02 1.01 (1.01–1.02) <  0.01   
Creatinine Clearance (ml·min− 1) 72 ± 29 57 ± 22 <  0.01 0.97 (0.95–0.99) <  0.01 0.97 (0.95–0.99) <  0.01