Clinical significance and prognosis of serum tenascin-C in patients with sepsis

BMC Anesthesiology

Table 1 Characteristics of the study subjects

Variable	Sepsis patients n = 167	Survivors n = 109	Nonsurvivors n = 58	P value
Male sex^a	107 (64.1%)	70 (64.2%)	37 (63.8%)	0.956
Age (years)^b	60 (51–67)	57 (48.5–65)	62 (55–69)	0.024
Site of infection^a				0.241
Pulmonary	111 (66.5%)	68 (62.4%)	43 (74.1%)
Abdominal	38 (22.8%)	29 (26.6%)	9 (15.5%)
Other	18 (10.8%)	12 (11.0%)	6 (10.3%)
SOFA score^b	12 (10–13)	11 (10–13)	13 (11–14)	< 0.001
Mechanical ventilation^a	87 (52.1%)	49 (45.0%)	38 (65.5%)	0.011
ICU time (days)^b	7 (5–10)	7 (5–9)	7 (5–10)	0.573
Septic shock^a	93 (55.7%)	50 (45.9%)	43 (74.1%)	< 0.001
Serum creatinine (μmol/L)^b	110 (85–136)	104 (79.5–128.5)	121 (105–146)	0.001
Lactic acid (mmol/L)^b	2.8 (2.5–3.2)	2.7 (2.5–3.1)	2.9 (2.6–3.3)	0.008
WBC (10³ cells/μL)^b	15 (13–17)	15 (13–17)	15 (13–17)	0.609
CRP (pg/mL)^b	198 (176–231)	190 (173–225)	207 (187–238)	0.01
IL-6 (pg/mL)^b	397 (345–465)	388 (327–458)	416 (376–509)	0.01
TNF-α (pg/mL)^b	41 (36–47)	39 (35–45)	44 (38–50)	0.001

SOFA Sepsis-related Organ Failure Assessment, ICU intensive care unit, WBC white blood cell count, CRP C-reactive protein, IL-6 Interleukin 6, TNF-α Tumor necrosis factor-α
^aCategorical Variable are expressed as frequency (%) and analyzed by Chi-squared test
^bContinuous variable are expressed as median (25th to 75th percentiles) and analyzed by Mann-Whitney U test

ISSN: 1471-2253