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Table 4 Cox proportional hazards regression for cancer-specific survival (n = 430)

From: Epidural anesthesia and cancer outcomes in bladder cancer patients: is it the technique or the medication? A matched-cohort analysis from a tertiary referral center

Covariate

Level

Univariable Hazard Ratio (95% CI)

P-value

aMultivariable Hazard Ratio (95% CI)

P-value

Age

 

0.99 (0.97–1.01)

0.448

  

Gender

Male

1.14 (0.70–1.85)

0.600

  

Female

Ref

   

ASA

≥ 3

1.24 (0.85–1.82)

0.256

  

≤ 2

Ref

   

Anesthesia

GA + Epidural

1.33 (0.91–1.95)

0.146

1.53 (1.04–2.25)

0.030

GA

Ref

   

pN stage

N+

3.70 (2.52–5.43)

< 0.001

2.48 (1.64–3.74)

< 0.001

N0/Nx

Ref

   

pT stage

≥ T3

4.98 (3.31–7.51)

< 0.001

3.63 (2.32–5.68)

< 0.001

≤ T2

Ref

   

Margin (radial/ureteral/urethral)

Positive

2.38 (1.56–3.62)

< 0.001

2.00 (1.29–3.09)

0.012

Negative

Ref

   

Neoadjuvant chemotherapy

Yes

1.34 (0.90–1.99)

0.151

  

No

Ref

   

Adjuvant chemotherapy

Yes

2.03 (1.35–3.04)

0.0006

  

No

Ref

   
  1. aResults are from a backwards selection process (significance level at 0.05)
  2. Bold value indicates statistical significance