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Table 4 Serum Levels of Ngb, HIF-1α and NSE(n = 40 in Each Group)

From: Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial

 

Group

T0

T1

T2

T3

T4

T5

T6

Ngb

C

1.23 ± 0.42

0.53 ± 0.19*

0.93 ± 0.43*

2.83 ± 1.14*

1.89 ± 0.77*

1.92 ± 0.83*

2.33 ± 0.74*

(ng/mL)

S

1.35 ± 0.39

0.61 ± 0.23*

0.93 ± 0.32*

1.20 ± 0.61‡

1.62 ± 0.59†

1.94 ± 0.80*

2.35 ± 0.83*

HIF-1α

C

2.01 ± 0.55

4.54 ± 1.38*

10.98 ± 2.55*

6.56 ± 2.06*

2.48 ± 0.99*

2.04 ± 0.62

2.33 ± 1.12

(ng/mL)

S

1.93 ± 0.68

2.37 ± 1.04*‡

9.11 ± 1.49*‡

4.69 ± 2.01*‡

2.36 ± 1.30†

2.15 ± 0.90

1.98 ± 0.77

NSE

C

5.05 ± 1.21

18.47 ± 5.72*

34.93 ± 12.33*

40.77 ± 15.73*

14.25 ± 5.67*

9.54 ± 3.50*

12.27 ± 5.76*

(ng/mL)

S

5.28 ± 1.35

17.67 ± 5.51*

33.82 ± 12.78*

27.96 ± 6.53*‡

10.51 ± 4.94*‡

8.25 ± 3.61*

6.44 ± 1.35*‡

  1. T0, 30 min after the induction; T1, immediately after temperature rewarmed to 36 °C; T2, end of cardiac surgery; T3–6, 6 h, 24 h, 48 h, 72 h after CPB
  2. Data are expressed as mean ± SD
  3. * p < 0.01 vs. T0.† p < 0.05 vs. T0.‡ p < 0.01 vs. group C