Table 2 Lung mechanics and gas-exchange data. Data are presented as mean (standard deviation) and median (quartiles)
Control group (n = 21) | Dexmedetomidine group (n = 21) | P value | |
|---|---|---|---|
P/F ratio | |||
- Baseline | - 305 (68) | - 298 (52) | - 0.7 |
- 45 min | - 300 (45) | - 305 (54) | - 0.7 |
- 90 min | - 303 (59) | - 330 (61)b | - 0.2 |
- Delta P/F ratio | - -2 (60)a | - 32 (43) | - 0.046 |
Dynamic compliance (mL cmH2O− 1) | |||
- Baseline | - 35.6 (7) | - 40 (9) | - 0.07 |
- 45 min | - 34.6 (5)a | - 41.3 (8) | - 0.004 |
- 90 min | - 34.5 (6)a | - 44.5 (9)b | - < 0.001 |
- Delta compliance | - -1 (4)a | - 4 (4) | - < 0.001 |
Static compliance (mL cmH2O− 1) | |||
- Baseline | - 45 (12) | - 51 (14) | - 0.14 |
- 45 min | - 44 (9) | - 51 (12) | - 0.057 |
- 90 min | - 45 (11) a | - 54 (13) | - 0.01 |
- Delta compliance | - −0.7 (7) | - 3 (8) | - 0.1 |
Dead space (%) | |||
- Baseline | - 18 (6) | - 20 (8) | - 0.3 |
- 45 min | - 21 (8)b | - 19 (6) | - 0.4 |
- 90 min | - 22 (8)a, b | - 17 (5)b | - 0.02 |
- Delta dead-space % | - 3.4 (0.3,6.5)a | - − 1.6(− 8,1.5) | - 0.01 |
PaCO2 (mmHg) | |||
- Baseline | - 42.3 (7) | - 39.5 (5) | - 0.1 |
- 45 min | - 45.7 (7)b | - 42 (7)b | - 0.08 |
- 90 min | - 46.8 (6)b | - 43 (7)b | - 0.052 |
- Delta PaCO2 | - −4.4 (6) | - −3.5 (6) | - 0.6 |