Evaluation of the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease

Table 1 Demographic data, baseline characteristics, and patient outcomes. Data are presented as mean (standard deviation), median (quartiles), and frequency (%)

	Control group (n = 21)	Dexmedetomidine group (n = 21)	P value
Age (years)	32 (5)^a	29 (4)	0.05
BMI (kg/m²)	45 (3)^a	48 (4)	0.03
Smoking	5 (25%)	6 (29%)	0.95
COPD, emphysema	0(%)	0 (0%)	1
FVC (% predicted)	65 (61,67)	62 (60,66)	0.28
FEV1/FVC (%)	81 (78,84)	80 (77,83)	0.33
Baseline PaCO₂ (mmHg)	42 (7)	39 (5)	0.1
Surgical duration	113 (19)	109 (18)	0.5
Intraoperative fluids	844 (101)	831 (103)	0.7
Blood loss	238 (76)	258 (78)	0.4
Postoperative complications
- ICU admission	3 (14%)	2 (10%)	0.9
- Invasive ventilation	2 (10%)	1 (5%)	1
- Anastomotic leakage	0 (0%)	0 (0%)	1
- Bleeding	0 (0%)	0 (0%)	1
- Pneumonia	0 (0%)	0 (0%)	1
- 28-day death	0 (0%)	0 (0%)	1
POSS	2 (1,2)	2 (1,2)	1

BMI Body mass index, COPD Chronic obstructive pulmonary disease, FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity, ICU intensive care unit, POSS Pasero opioid-induced sedation scale, P/F ratio PaO2/fraction of inspired oxygen
^adenotes statistical significance between both groups

ISSN: 1471-2253