Table 1 Study characteristics and overall risk-of-bias assessment for each study
Trial/author, year [reference] | Number of patients | Nature of surgery | Goal-directed hemodynamic therapy | Overall risk of bias | ||
|---|---|---|---|---|---|---|
Goal | Monitoring method | Type of α1 adrenergic agonists application | ||||
Bartha et al., 2013 [24] | 149 | Proximal femoral fracture | DO2I > 600 mL/(min · m2), ΔSV < 10% | Pulse contour analysis monitor | Phenylephrine | High |
Benes et al., 2015 [25] | 80 | Total knee and hip replacement | PPV < 13% | Pulse contour analysis monitor | Norepinephrine | Low |
Bisgaard, et al., 2013 [26] | 64 | Abdominal aortic surgery | SVI < 10%, DO2I ≥ 600 mL/(min · m2) | Pulse contour analysis monitor | Phenylephrine | Low |
Broch et al., 2016 [27] | 79 | Major abdominal surgery | PPV ≤10%; CI ≥2.5 L/(min · m2) MAP ≥65 mmHg | Noninvasive hemodynamic optimization | Norepinephrine | Unclear |
Elgendy et al., 2017 [28] | 86 | Major abdominal surgery | SVV ≤12%; CI ≥2.5 L/(min · m2) MAP ≥65 mmHg | Pulse contour analysis monitor | Norepinephrine | Low |
Forget et al., 2010 [29] | 82 | Major abdominal surgery | PVI < 13% | Pulse oximeter | Norepinephrine | Low |
Funk et al., 2015 [30] | 40 | Open abdominal aortic aneurysm repair | SVV ≤13%, CI ≥2.2 L/(min · m2) | Pulse contour analysis monitor | Norepinephrine | Low |
Gan et al., 2002 [31] | 100 | Major abdominal surgery | FTc > 0.40 s, ΔSV < 10% | Esophageal Doppler | Phenylephrine | High |
Gómez-Izquierdo et al., 2017 [32] | 128 | Elective laparoscopic colorectal surgery | ΔSV < 11% | Esophageal Doppler | Phenylephrine | Low |
Hand et al., 2016 [33] | 94 | Free tissue transfer reconstruction | SVV ≤12%; CI ≥3.0 L/(min · m2), MAP > 75 mmHg | Pulse contour analysis monitor | Phenylephrine | High |
Kaufmann et al., 2017 [34] | 96 | Thoracic surgery | ΔSV < 10%; CI ≥2.5 L/(min · m2), MAP ≥70 mmHg | Esophageal Doppler | Norepinephrine | Low |
Kumar et al., 2015 [35] | 40 | Major abdominal surgery | SVV ≤10%; O2ER < 27%, MAP > 65 mmHg | Pulse contour analysis monitor | Norepinephrine | Unclear |
Luo et al., 2017 [36] | 145 | Brain surgery | SVV ≤15%; CI ≥2.5 L/(min · m2), MAP ≥65 mmHg | Pulse contour analysis monitor | Norepinephrine | Low |
Malbouisson et al., 2017 [37] | 168 | Open major surgery | PPV ≤10% | Pulse contour analysis monitor | Norepinephrine | High |
Mayer et al., 2010 [38] | 60 | High-risk surgical | SVV ≤12%; CI ≥2.5 L/(min · m2), SVI ≥35 mL/m2, MAP > 65 mmHg | Pulse contour analysis monitor | Norepinephrine | Low |
Moppett et al., 2015 [9] | 114 | Hip fracture surgery | ΔSV < 10% | Pulse contour analysis monitor | Metaraminol | High |
Peng et al., 2014 [39] | 80 | Major orthopedic surgery | SVV ≤10% | Pulse contour analysis monitor | Phenylephrine | High |
Pestaña et al., 2014 [40] | 142 | Major abdominal surgery | CI ≥2.5 L/(min · m2), MAP ≥65 mmHg | Noninvasive cardiac output monitor | Norepinephrine | Low |
Pösö et al., 2014 [41] | 46 | Laparoscopic bariatric surgery | SVV < 12%, CO, SV, and MAP > 70% baseline | Pulse contour analysis monitor | Phenylephrine | High |
Reisinger et al., 2017 [42] | 58 | Colorectal surgery | ΔSV < 10%, MAP ≥65 mmHg | Esophageal Doppler | Phenylephrine | Low |
Salzwedel et al., 2013 [43] | 160 | Major abdominal surgery | PPV ≤10%; CI ≥2.5 L/(min · m2), MAP ≥65 mmHg | Pulse contour analysis monitor | Norepinephrine, phenylephrine | High |
Scheeren et al., 2013 [3] | 52 | High-risk surgery | SVV ≤10%, ΔSV < 10% | Pulse contour analysis monitor | Norepinephrine | High |
Schmid et al., 2016 [44] | 180 | Major abdominal surgery | GEDI ≤800; CI ≥2.5 L/(min · m2), ELWI ≥10 mL/m2, MAP ≥70 mmHg | Transpulmonary thermodilution monitor | Norepinephrine | Low |
Stens et al., 2017 [45] | 175 | Moderate-risk abdominal surgery | PPV < 12%, CI ≥2.5 L/(min · m2), MAP ≥70 mmHg | Pulse contour analysis monitor | Norepinephrine | Low |
Veelo et al., 2017 [46] | 199 | Esophageal surgery | ΔSV < 10%, MAP ≥65 mmHg | Pulse contour analysis monitor | Norepinephrine, Phenylephrine | Unclear |
Wagar et al., 2017 [47] | 67 | Total pancreatectomy and islet cell autotransplantation | SVV < 12%; CI ≥2.5 L/(min · m2); MAP > 10% baseline | Pulse contour analysis monitor | Phenylephrine | Unclear |
Weinberg et al., 2017 [48] | 52 | Pancreaticoduodenectomy | SVV ≤20%, MAP ≥20% baseline | Pulse contour analysis monitor | Norepinephrine | Low |
Wu et al., 2017 [49] | 63 | Supratentorial neoplasms surgery | SVV ≤12%, CI ≥2.5 L/(min · m2) | Pulse contour analysis monitor | Phenylephrine | Low |
Xu et al., 2017 [50] | 168 | Elective thoracoscopic lobectomy | SVV ≤13%; CI > 2.5 L/(min · m2), ΔSV ≤10%, MAP > 65 mmHg | Pulse contour analysis monitor | Norepinephrine | Low |
Zhang et al., 2013 [51] | 60 | Thoracoscopy lobectomy | SVV < 9%, CI ≥2.5 L/(min · m2) | Pulse contour analysis monitor | Phenylephrine | Low |
Zheng et al., 2013 [52] | 60 | Gastrointestinal surgery | SVI ≤35 mL/m2; MAP > 65 mmHg; SVV < 12%; CI ≥2.5 L/(min · m2) | Pulse contour analysis monitor | Norepinephrine | Low |