Cost-effectiveness of anesthesia maintained with sevoflurane or propofol with and without additional monitoring: a prospective, randomized controlled trial

Table 5 Cost elements of anesthesia II – group SEVO compared to PROP and group SEVO+ compared to PROP+

Costs	SEVO (n = 30)	PROP (n = 30)	p value	SEVO+ (n = 30)	PROP+ (n = 29)	p value
Induction of anesthesia (€)
Fentanyl	0.19 ± 0.03	0.19 ± 0.02	1.000	0.20 ± 0.03	0.20 ± 0.02	1.000
Propofol	1.16 ± 0.16	1.14 ± 0.08	0.996	0.94 ± 0.19	0.81 ± 0.20	0.205
Atracurium	2.44 ± 0.27	2.22 ± 0.55	0.253	2.37 ± 0.42	2.30 ± 0.36	1.000
Conduct of anesthesia (€/hour)
Fentanyl	0.12 ± 0.08	0.18 ± 0.08	< 0.001	0.12 ± 0.09	0.20 ± 0.07	< 0.001
Atracurium	0.58 ± 0.40	0.67 ± 0.55	1.000	0.52 ± 0.42	0.56 ± 0.39	1.000
Hypnotic agent	4.62 ± 2.03	4.12 ± 1.61	< 0.001	3.39 ± 0.91	3.08 ± 0.85	< 0.001
Other drugs (€/hour)	1.51 ± 2.14	1.83 ± 1.15	0.958	1.22 ± 1.99	1.60 ± 2.01	1.000
Summary of costs
Total drug (€/hour)	8.84 ± 4.11	8.33 ± 3.02	< 0.001	7.86 ± 3.54	7.52 ± 2.49	< 0.001
Total disposables (€)	6.49 ± 0.11	8.09 ± 0.07	< 0.001	23.25 ± 0.12	24.76 ± 0.19	< 0.001
Total cost of anesthesia (€/hour)	12.15 ± 5.32	13.23 ± 4.23	< 0.001	19.95 ± 8.53	22.11 ± 8.08	< 0.001

Values are expressed as mean ± standard deviation; SEVO Sevoflurane anesthesia without additional monitoring; SEVO+ Sevoflurane anesthesia with BIS and TOF monitoring; PROP Propofol anesthesia without additional monitoring; PROP+ Propofol anesthesia with BIS and TOF monitoring; Hypnotic agent in groups SEVO and SEVO+ was sevoflurane; Hypnotic agent in groups PROP and PROP+ was propofol; Other drugs Antidotes (neostigmine and atropine mixture, nalbuphine, and flumazenil) and postoperative pain management

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