Evaluation of a combination “lymphocyte apoptosis model” to predict survival of sepsis patients in an intensive care unit

Table 4 Value of APACHE, II, SOFA, and lymphocyte apoptosis model for predicting 28-day mortality

Variables	ROC curve			Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Variables	AUC (95%CI)	Best cutoff	p	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
lymphocyte apoptosis model predicted value	0.955(0.901–1.000)	0.286	<0.001	94.1	91.4	91.1	94.3
lymphocyte apoptotic percentage (%)	0.834(0.713–0.955)^a	28.87	<0.001	82.4	85.7	73.2	90.9
cytc (ng/mL)	0.729(0.584–0.847)^a	1.28	0.008	76.5	60.0	48.2	84.0
lymphocyte count (1 × 10⁹/L)	0.802(0.654–0.949)^a	0.59	<0.001	94.3	70.6	60.9	96.2
HLA-DR (%)	0.773(0.632–0.914) ^a	82.68	0.002	88.6	64.7	54.9	92.1
APACHE II score	0.696(0.550–0.842)^a	14.5	0.023	70.6	68.6	67.0	72.1

^ap < 0.05 compared with the lymphocyte apoptosis model predictive value
APACHE acute physiology and chronic health evaluation, AUC area under the curve, CI confidence interval, Cyt-c cytochrome c, NPV negative predictive value, PPV positive predictive value, ROC receive operating characteristic, SOFA sequential organ failure assessment

ISSN: 1471-2253