In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients

BMC Anesthesiology

Table 3 Linear mixed-effects regression model for the effect of exogenous sugammadex on thromboelastographic parameters

	Intercept	β coefficient (standard error)	P value
R^a (min) 2–8	5.9	0.008 (0.002)	0.002
K^b (min) 1–3	1.7	0.003 (0.001)	0.018
Angle^c (degrees) 55–78	64.5	−0.032 (0.011)	0.009
MA^d (min) 51–69	66.7	−0.021 (0.009)	0.028
G^e (dynes (cm²)⁻¹) 4.6–10.9 K	10.6	−0.008 (0.003)	0.024
Ly30 (%) 0–8	1.3	−0.003 (0.001)	0.010
MRTG^g (mm min⁻¹) 5–17	12.3	−0.009 (0.004)	0.036
TMRTG^h (min) 6–12	7.2	0.010 (0.003)	0.002
TTGⁱ (mm min⁻¹) 584–796	805.8	−0.246 (0.108)	0.033

The average baseline r time calculated using mixed model repeated linear regression was 5.9 min; the rate of change of r time was 0.008 min per 1 μg mL^− 1 increase in exogenous sugammadex concentration. ^aR, reaction time to clot formation; ^bK, time to achieve a clot strength of 20 mm amplitude; ^cAngle, rate of clot growth; ^dMA, maximum amplitude of clot strength; ^eG, shear elastic modulus strength; ^gMRTG, maximum rate of thrombus generation; ^hTMRTG, time to maximum rate of thrombus generation; ⁱTTG, total thrombin time

ISSN: 1471-2253