In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients

BMC Anesthesiology

Table 2 Thromboelastographic parameters from citrated whole blood and citrated whole blood treated with exogenous sugammadex (42, 193, and 301 μg mL^− 1) collected from patients who underwent orthopedic surgery

	Exogenous sugammadex concentration (μg mL^− 1)
	0	42	193	301	P
R^a (min) 2–8	5.6 (1.2)	6.3 (1.5)***	7.9 (1.9)^◇◇◇,****	8.2 (2.4)^,****	< 0.0001
K^b (min) 1–3	1.7 (0.4)	1.8 (0.5)	2.3 (0.7)^◇,*	2.5 (1.2)^{□, *,}	0.0018
Angle^c (degrees) 55–78	64.5 (8.6)	64.8 (6.7)	54.0 (10.9) ^◇,*	56.5 (10.8)^□,*	0.0004
MA^d (min) 51–69	67.9 (6.8)	64.8 (6.0)*	61.8 (8.0)*	60.5 (8.9)^{□, **}	0.0008
G^e (dynes (cm²)⁻¹) 4.6–10.9 K	11.3 (4.0)	9.6 (2.5)	8.7 (2.9)	8.3 (3.1)*	0.0065
Ly30 (%) 0–8	1.1 (1.0)	1.3 (1.0)	0.9 (1.1)	0.3 (0.5)^{□□, *}	0.0461
MRTG^g (mm min⁻¹) 5–17	12.7 (3.3)	11.8 (3.0)	10.3 (3.4)*	9.9 (3.7)**	0.0021
TMRTG^h (min) 6–12	7.0 (1.5)	7.7 (1.7)**	9.5 (2.3)^◇◇◇,***	10.0 (2.9)^□□□,***	< 0.0001
TTGⁱ (mm min⁻¹) 584–796	821 (83.1)	781.2 (70.3)*	749.7 (97.0)*	733.7 (106.2)**	0.0010

The values presented are the mean (SD), n = 14. Holm-Sidak’s multiple comparisons test was performed to compare the significance of the differences between each study solution. ^aR, reaction time to clot formation; ^bK, time to achieve a clot strength of 20 mm amplitude; ^cAngle, rate of clot growth; ^dMA, maximum amplitude of clot strength; ^eG, shear elastic modulus strength; ^gMRTG, maximum rate of thrombus generation; ^hTMRTG, time to maximum rate of thrombus generation; ⁱTTG, total thrombin time; Statistically significant differences between; (301 vs 193), □ (301 vs 42), ◇ (193 vs 42) and * (control). Single symbol and * indicate P < 0.05 compared with control value; two symbols □□ and ** indicate P < 0.01; and three symbols □□□, ◇◇◇, and *** indicate P < 0.001, **** indicate P < 0.0001

ISSN: 1471-2253