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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Ketamine exacerbates cortical neuroapoptosis under hyperoxic conditions by upregulating expression of the N-methyl-D-aspartate receptor subunit NR1 in the developing rat brain

Fig. 1

Ketamine or ketamine + hyperoxia promotes apoptosis in the frontal cortex. a TUNEL assay on paraffin-embedded coronal sections of frontal cortex from rat pups. Green fluorescence indicates TUNEL-positive cells. Blue fluorescence indicates DAPI staining of nuclei. Scale bar: 20 μm. b Quantification of TUNEL-positive cells in frontal cortex (mean ± SD; n = 6 rats per group). The apoptotic index was calculated as the number of DAPI- and TUNEL-positive cells divided by the number of DAPI-positive cells. **P < 0.01 vs. control; ##P < 0.01 vs. ketamine

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BMC Anesthesiology

ISSN: 1471-2253

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