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Table 1 Mean values with standard error (SEM) for Aβ plaque deposition and synaptophysin immunoreactivity data

From: Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer’s disease mice

 

APP/PS1

APP/PS1

 

Propofol

Vehicle

Aβ plaque load

3.85 ± 1.0%

3.80 ± 0.8%

Aβ plaque size

37.4 ± 6.6 μm2

41.6 ± 6.5 μm2

Aβ plaque density

0.041 ± 0.009/μm2

0.030 ± 0.007/μm2

Synapse density R1

0.366 ± 0.03/μm2

0.359 ± 0.017/μm2

Synapse % area R1

1.63 ± 0.17%

1.55 ± 0.12%,

Synapse density R2

0.234 ± 0.085/μm2

0.268 ± 0.060/μm2

Synapse % area R2

2.37 ± 0.90%

2.57 ± 0.63%

  1. Aβ plaque load and Aβ plaque density were determined using the MOAβ-2 antibody in propofol (n = 8) and vehicle (n = 6) treated APP/PS1 mice
  2. Synapse density and percentage area were analyzed in vehicle (n = 3) and propofol (n = 3) treated APP/PS1 mice in: Region 1 (R1), < 40 μm from Thioflavin-S plaques: and Region 2 (R2) = 40-80 μm away from Thioflavine-S plaques