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Table 2 Efficacy outcomes

From: Dexmedetomidine infusion as an analgesic adjuvant during laparoscopic сholecystectomy: a randomized controlled study

Outcome

Group D

Group C

p-value

Postoperative morphine consumption in 24 h (mg)

5 (0–10)

15 (10–20)

0.0012

Cumulative morphine consumption (mg)

15 (10–25)

30 (20–30)

0.0012

Severe pain incidence; n (%)

1 (3)

7 (23)

0.041

Time to first use of rescue analgesia (min)

180 (130–210)

80 (60–120)

0.0012

Time to extubation (min)

10 (5–10)

20 (15–20)

0.0012

Postoperative pain level (VRS score)

 3 h

3 (3–4)

4 (4–5)

0.0672

 6 h

4 (4–5)

5 (4–5)

0.082

 12 h

3 (3–3)

4 (4–5)

0.332

 24 h

4 (4–4)

4 (4–4)

0.722

Intraoperative fentanyl consumption (mg)

0.5 (0.4–0.6)

0.6 (0.5–0.7)

0.032

Persistent postsurgical pain incidence; n (%)

1 (3)

10 (33)

0.0051

  1. Unless specified otherwise, values are expressed as medians, with 25–75% interquartile ranges in parentheses. VRS: verbal rating scale
  2. 1Fisher test, 2Mann-Whitney test