Consequences of continuing renin angiotensin aldosterone system antagonists in the preoperative period: a systematic review and meta-analysis

Ling, Qiong; Gu, Yu; Chen, Jiaxin; Chen, Yansheng; Shi, Yongyong; Zhao, Gaofeng; Zhu, Qianqian

doi:10.1186/s12871-018-0487-7

Table 1 Characteristics of studies included in meta-analysis

From: Consequences of continuing renin angiotensin aldosterone system antagonists in the preoperative period: a systematic review and meta-analysis

Author, year	Country	Type of surgery	Type of anesthesia	Number of participants	Female (%)	Age (Mean)	Postoperative complications	Definition of hypotension	Type of study	Quality scoreⁱ
Bertrand, 2001 [7]	France	Elective major vascular sugery	General	37	12.2	68	ST-T abnormalities	SBP^a< 80 mmHg	RCT	RCT
Brabant, 1999 [12]	France	Elective vascular surgery	General	39	16.7	69	MI^b	SBP < 90 mmHg or 30% baseline	Prospective observational	8
Calloway, 2014 [13]	USA	Total knee arthroplasty	Neuraxial	60	61	66	MI, stroke/TIA^c, AKI^d, death	SBP ≤85 mmHg	Retrospective observational	8
Colson, 1992 [18]	France	Coronary artery bypass graft surgery	General	16	12.5	65	N/A^e	MAP^f < 70 mmHg	Prospective observational	6
Comfere, 2005 [15]	USA	Non-cardiovascular	General	267	44	66(Median)	MI, stroke, AKI, death	SBP ≤85 mmHg	Retrospective observational	9
Coriat, 1994 [16]	France	Peripheral vascular	General	51	N/A	67	N/A	SBP < 90 mmHg	RCT^g	RCT
Licker, 2000 [19]	Switzerland	Coronary artery bypass graft	General	32	22	60	N/A	SBP < 90 mmHg	Prospective observational	7
Pigott, 1999 [9]	UK	Coronary artery bypass graft	General	40	12.5	63	N/A	SBP < 85 mmHg	RCT	RCT
Roshanov, 2017 [20]	Eight countries	Noncardiac Surgery	NA	4802	N/A	N/A	myocardial injury, stroke, death	SBP < 90 mmHg	Prospective observational	8
Ryckwaert, 1997 [14]	France	Coronary artery bypass graft	General	18	11	62	N/A	70mmHg	Prospective observational	7
Salvetti, 2016 [17]	Italy	Elective bariatric surgery	General	26	73%	47	N/A	N/A	Prospective observational	8
Steely, 2016 [21]	New England	Carotid endarterectomy	General/ Neuraxial	2878	N/A	N/A	MACE^h, stroke/ death	N/A	Retrospective observational	9
Zainudheen, 2017 [22]	Woolloongabba	Elective orthopaedic surgery	General/ Neuraxial	258	58.5%	69.8	MACE, AKI	SBP < 90 mmHg	Retrospective observational	7

^a, SBP, systolic blood pressure; ^b, MI, myocardial infarction; ^c, TIA, transient ischemic attack; ^d, AKI, acute kidney injury; ^e, N/A, not available;^f, mean arterial pressure; ^g, RCTs, randomized controlled trials; ^h, MACE, major adverse cardiac event
ⁱthe quality score was assessed with the use of the Newcastle–Ottawa Scale (NOS)

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ISSN: 1471-2253

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