Fig. 2
Comparison of blood vessel density in the ischemic penumbra at 7d after I/R. Compared with sham group, the new vessel density of ischemia penumbra in rats of MCAO group rose respectively at 7 d after focal cerebral I/R injury; Compared with Vehicle group, the new vessel density of ischemia penumbra in rats of HPX group saw a marked increase respectively at 7 d after focal cerebral I/R injury; When the inhibitor of HO-1, ZnPPIX, was given along with HPX simultaneously to rats after focal cerebral I/R injury, the positive effect of HPX on enhancing the neovascularization of ischemia penumbra was significantly blocked respectively. However, there was no statistical difference in terms of the new vessel density of ischemia penumbra in rats between MCAO and MCAO + Vehicle group at 7 d after focal cerebral I/R injury respectively. Scale bars = 20 μm