Neuroprotective effects of amiodarone in a mouse model of ischemic stroke

BMC Anesthesiology

Table 1 Hemodynamic measurements

Group		SBP	DBP	HR
Group		(mmHg)	(mmHg)	(beats/min)
Control	-1 h (Baseline)	109 ± 6	64 ± 6	469 ± 10
	0 h (MCAO)	106 ± 7	63 ± 6	470 ± 14
	1 h	124 ± 5	62 ± 8	526 ± 24
	48 h	116 ± 7	63 ± 11	490 ± 15
Amiodarone Pre-treatment	-1 h (Baseline)	107 ± 8	64 ± 5	477 ± 11
	0 h (MCAO)	102 ± 9	60 ± 7	382 ± 23*
	1 h	119 ± 8	60 ± 8	444 ± 28*
	48 h	113 ± 6	64 ± 7	450 ± 22*
Amiodarone Post-treatment	-1 h (Baseline)	108 ± 6	63 ± 5	474 ± 17
	0 h (MCAO)	109 ± 7	63 ± 6	471 ± 13
	1 h	117 ± 11	59 ± 12	416 ± 12*
	48 h	116 ± 13	64 ± 8	456 ± 18*
Amiodarone Pre-treatment + Veratrine	-1 h (Baseline)	110 ± 9	63 ± 7	485 ± 24
	0 h (MCAO)	114 ± 11	64 ± 8	424 ± 14*
	1 h	119 ± 9	63 ± 7	425 ± 16*
	48 h	113 ± 7	68 ± 4	491 ± 23
Amiodarone Pre-treatment + Isoproterenol	-1 h (Baseline)	109 ± 8	64 ± 9	465 ± 20
	0 h (MCAO)	100 ± 6	58 ± 4	472 ± 16
	1 h	110 ± 6	65 ± 4	440 ± 31*
	48 h	106 ± 8	64 ± 4	471 ± 37

Heart rate was lower in the amiodarone pre-treatment group, amiodarone post-treatment group, and amiodarone + veratrine group than in the control mice at the time of MCAO
There was a trend toward slightly lower systolic blood pressure and diastolic blood pressure for animals that received 50 mg/kg amiodarone; however, the difference was not statistically significant (*P < 0.05 vs. control)
Abbreviations: SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, MCAO middle cerebral artery occlusion

ISSN: 1471-2253