Perioperative Duloxetine and Etoricoxibto improve postoperative pain after lumbar Laminectomy: a randomized, double-blind, controlled study

Table 2 Pain scores (NRS) at rest in the four groups

Group Variable	Group (P) (n = 30)	Group (E) (n = 30)	Group (D) (n = 30)	Group (D/E) (n = 30)	P value
At 0 h	5 (4-5.25)^bd	4 (3-4) ^acd	4 (3-5) ^bd	3 (3-4) ^abc	0.0001
At 2 h	4 (3-5)bd	3 (3-4) ^acd	4 (3-5) ^bd	3 (3-3)^abc	0.0001
At 4 h	4 (3-5) ^bd	3 (3-4) ^acd	3 (3-4) ^bd	2 (2-3)^abc	0.0001
At 6 h	3 (3-4) ^bd	3 (2-4) ^ad	2.5 (2-3)^d	2 (1-3) ^abc	0.0001
At 12 h	3 (3-3) ^bd	3 (2-3) ^ad	3 (2-3)^d	2.5 (1-3) ^abc	0.0001
At 24 h	3 (2-3) ^bcd	2(2-3) ^ad	2.5 (2-3) ^ad	2 (1-2)^abc	0.0001
At 48 h	3 (2-3) ^bcd	2 (2-3) ^ad	2 (2-3) ^ad	2 (0.75-2)^abc	0.0001

Placebo group (P), Etoricoxib (E), Duloxetine (D), Duloxetine/Etoricoxib (D/E)
Data are presented as median (interquartile range). Data were analyzed by Mann–Whitney U-test and kruksal-wallis test and P < 0.05 is considered significant
a: when compared with P group
b: when compared with E group
c: when compared with D group
d: when compared with D/E group

ISSN: 1471-2253