Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells

Table 4 Effects of propofol on TNF-α secretion in RAW264.7 cells (M ± SD, n = 4)

Groups	M ± SD (pg/mL)		Groups	M ± SD (pg/mL)	Statistical value	P value
Blank control group	213.20 ± 40.09	VS	LPS intervention	2102.34 ± 150.60	−21.077	0.0001
			Low-dose of propofol	1562.20 ± 267.15	−8.656	0.001
			High-dose of propofol	1129.21 ± 187.96	−5.181	0.007
LPS intervention	2102.34 ± 150.60		Low-dose of propofol	1562.20 ± 267.15	3.055	0.038
LPS intervention	2102.34 ± 150.60		High-dose of propofol	1129.21 ± 187.96	7.031	0.002
Low-dose of propofol	1562.20 ± 267.15		High-dose of propofol	1129.21 ± 187.96	2.301	0.083

M ± SD mean ± standard deviation, Blank control group without any intervention, LPS intervention group 250 ng/mL LPS, Low-dose group of propofol treatment plus 250 ng/mL LPS and 25 μmol/L propofol, High-dose group of propofol treatment plus 250 ng/mL LPS and 50 μmol/L propofol

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