Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells

Table 3 Effects of propofol on IL-8 secretion in RAW264.7 cells (M ± SD, n = 4)

Groups	M ± SD (pg/mL)		Groups	M ± SD (pg/mL)	Statistical value	P value
Blank control group	34.54 ± 8.61	VS	LPS intervention	185.64 ± 21.12	−11.646	0.0001
			Low-dose of propofol	120.03 ± 11.35	−10.887	0.0001
			High-dose of propofol	70.56 ± 9.19	−5.181	0.007
LPS intervention	185.64 ± 21.12		Low-dose of propofol	120.03 ± 11.35	4.794	0.009
LPS intervention	185.64 ± 21.12		High-dose of propofol	70.56 ± 9.19	8.724	0.001
Low-dose of propofol	120.03 ± 11.35		High-dose of propofol	70.56 ± 9.19	6.029	0.004

M ± SD mean ± standard deviation, Blank control group without any intervention, LPS intervention group 250 ng/mL LPS, Low-dose group of propofol treatment plus 250 ng/mL LPS and 25 μmol/L propofol, High-dose group of propofol treatment plus 250 ng/mL LPS and 50 μmol/L propofol

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