Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells

Table 2 Effects of propofol on IL-6 secretion in RAW264.7 cells (M ± SD, n = 4)

Groups	M ± SD (ng/mL)		Groups	M ± SD (ng/mL)	Statistical value	P value
Blank control group	6.89 ± 3.51	VS	LPS intervention	50.64 ± 5.77	−7.150	0.002
			Low-dose of propofol	27.58 ± 4.04	−4.570	0.01
			High-dose of propofol	16.67 ± 4.30	−3.183	0.03
LPS intervention	50.64 ± 5.77		Low-dose of propofol	27.58 ± 4.04	3.272	0.031
LPS intervention	50.64 ± 5.77		High-dose of propofol	16.67 ± 4.30	5.463	0.005
Low-dose of propofol	27.58 ± 4.04		High-dose of propofol	16.67 ± 4.30	2.344	0.079

M ± SD mean ± standard deviation, Blank control group without any intervention, LPS intervention group 250 ng/mL LPS, Low-dose group of propofol treatment plus 250 ng/mL LPS and 25 μmol/L propofol, High-dose group of propofol treatment plus 250 ng/mL LPS and 50 μmol/L propofol

ISSN: 1471-2253