Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells

Table 1 The relative gray value of HMGB1 protein band in different groups (n = 4)

Groups	M ± SD		Groups	M ± SD	Statistical value	P value
Blank control group	36,010 ± 2550	VS	LPS intervention	71,070 ± 2178	10.46	0.001
			Low-dose of propofol	59,970 ± 2453	6.772	0.002
			High-dose of propofol	52,470 ± 2018	4.313	0.012
LPS intervention	71,070 ± 2178		Low-dose of propofol	59,970 ± 2453	3.386	0.027
LPS intervention	71,070 ± 2178		High-dose of propofol	52,470 ± 2018	3.443	0.026
Low-dose of propofol	59,970 ± 2453		High-dose of propofol	52,470 ± 2018	5.955	0.004

M ± SD mean ± standard deviation, Blank control group without any intervention, LPS intervention group 250 ng/mL LPS, Low-dose group of propofol treatment plus 250 ng/mL LPS and 25 μmol/L propofol, High-dose group of propofol treatment plus 250 ng/mL LPS and 50 μmol/L propofol

ISSN: 1471-2253