Fig. 2
Propofol affected the release of IL-6, IL-8 and TNF-α by in LPS-stimulated RAW 264.7 cells. a The level of IL-6 in blank control group was lower than that in LPS intervention group (★ p < 0.05); b The level of IL-8 in blank control group was lower than that in LPS intervention group (★ p < 0.05). c The level of TNF-α in blank control group was lower than that in LPS intervention group (★ p < 0.05); d. Either in low-dose or in high-dose group of propofol, the level of IL-6 was all lower than that in LPS intervention group (★ p < 0.05); e. Either in low-dose or in high-dose group of propofol, the level of IL-8 was all lower than that in LPS intervention group (★ p < 0.05), especially, the level of IL-8 in the propofol high dose group was significantly lower than that in the low dose group (★★ p = 0.004); f. Either in low-dose or in high-dose group of propofol, the level of TNF-α was all lower than that in LPS intervention group (★ p < 0.05). Blank control group, without any intervention; LPS intervention group, plus 250 ng/mL LPS; Low-dose group of propofol treatment, plus 250 ng/mL LPS and 25 μmol/L propofol; High-dose group of propofol treatment, plus 250 ng/mL LPS and 50 μmol/L propofol; LPS, lipopolysaccharide; IL-6, interleukin- 6; IL-8, interleukin-8; TNF-α, tumor necrosis factor-α; HMGB1, high-mobility group box 1