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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Propofol inhibits the release of interleukin-6, 8 and tumor necrosis factor-α correlating with high-mobility group box 1 expression in lipopolysaccharides-stimulated RAW 264.7 cells

Fig. 1

The expression of HMGB1 between different intervention groups by western blotting in RAW 264.7 cells. a Semi-quantitative analysis of western blotting showed that the expression of HMGB1 in blank control group ★ was lower than LPS intervention group ★★, low-dose group of propofol and high-dose group of propofol ★★★ respectively (p < 0.05); and, the expression of HMGB1 in low-dose group of propofol ★★ and high-dose group of propofol ★★★ was all lower than LPS stimulation group (p < 0.05); b The results of western blotting showed that the expression of HMGB1 in intervention groups stimulated by LPS was up-regulated, compared with the blank control group; however, the expression of HMGB1 in low-dose group of propofol and high-dose group of propofol was all lower than LPS stimulation group; Blank control group, without any intervention; LPS intervention group, plus 250 ng/mL LPS; Low-dose group of propofol treatment, plus 250 ng/mL LPS and 25 μmol/L propofol; High-dose group of propofol treatment, plus 250 ng / mL LPS and 50 μmol/L propofol LPS; Blank, control group; LPS, lipopolysaccharide; HMGB1, high-mobility group box 1

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BMC Anesthesiology

ISSN: 1471-2253

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