Assessment of Haemostasis in patients undergoing emergent neurosurgery by rotational Elastometry and standard coagulation tests: a prospective observational study

Table 5 Postoperative coagulation data and clinical outcome in patients undergoing emergent neurosurgery

Outcome	High Bleeders	Low Bleeders	P-value
Outcome	(N = 39)	(N = 53)	P-value
Coagulation testing one day after surgery
Platelets, 10³/ml*	109 (38)	159 (65)	0.002†
Quick, %^a	90 (72–99)	92 (75–100)	0.611^b
INR, a.u*	1.11 (0.13)	1.12 (0.12)	0.578†
Fibrinogen, g/L*	4.0 (1.2)	3.9 (1.2)	0.326†
EXTEM CT	57 (42–72)	55 (40–70)	0.641
EXTEM MCF	62 (50–74)	59 (48–71)	0.284
INTEM MCF	66 (59–75)	62 (56–71)	0.248
FIBTEM MCF	58 (51–65)	57 (50–64)	0.968
Clinical Outcome (in-hospital)
Composite Mortality - Morbidity	47 (88.7)	15 38.5	0.001
Mortality	14 (35.9)	11 (20.8)	0.107
Cardiovascular outcomes
Myocardial infarction/ischemia	1 (2.6)	0 (0.0)	0.424^c
Cardiac arrhythmia	3 (7.7)	5 (9.4)	1.000^c
Thromboembolic complication	1 (2.6)	2 (3.8)	1.000^c
Acute heart failure	1 (2.6)	2 (3.8)	1.000^c
Respiratory complications
Pneumonia	8 (20.5)	14 (26.4)	0.424
Acute Respiratory Distress Syndrome	0 (0.0)	1 (1.9)	1.000^c
Mechanical ventilation, days^{a, d}	3 (1–11)	3 (1–13)	0.673^b
Renal dysfunction
Reduction in GFR > 25%	6 (15.4)	3 (5.7)	0.161^c
Other complications
Infection	3 (7.7)	5 (9.4)	1.000^c
Postoperative bleeding	6 (15.4)	7 (13.2)	0.767
Length of stay
ICU, days^{a, d}	10 (3–19)	5.5 (3–16)	0.391^b
Hospital, days^{a, d}	31 (18–37)	23.5 (15–32)	0.173^b

Data given as number (percentage) unless otherwise indicated. GFR glomerular filtration rate, ICU intensive care unit
Chi-squared tests were used for statistical tests unless otherwise indicated;
^aData given as median (range)
^bWilcoxon rank sum test
^cFisher exact test
^dSurvivors only
*mean (standard deviation)
+unpaired Student t test

ISSN: 1471-2253