Assessment of Haemostasis in patients undergoing emergent neurosurgery by rotational Elastometry and standard coagulation tests: a prospective observational study

Table 3 Surgical characteristics and intraoperative fluid and hemostatic management

	High Bleeders	Low Bleeders	P-value
	(N = 39)	(N = 53)	P-value
Surgical features
Decompressive craniectomy	10 (25.6)	14 (26.4)	0.933
Subdural hematoma	11 (28.2)	14 (26.4)	0.849
Subarachnoid haemorrhage	12 (30.8)	13 (24.5)	0.469
Subdural hematoma & subarachnoid haemorrhage	6 (15.4)	7 (13.2)	0.767
Surgery time, (min)^c	190 (159–280)	156 (90–230)	0.012^d
Intraoperative Fluids
Crystalloids, ml/min^a	21.8 (10.4)	18.5 (16.4)	0.272^b
Colloids, ml/min^c	0 (0–2.8)	0 (0–0.8)	0.312^d
Blood products & haemostatic therapy
Blood transfusion	39 (100)	28 (52.8)	<0.001
Units/patient transfused^c	5 (3–7)	1 (1–2)	<0.001^d
Fresh frozen plasma	27 (69.2)	12 (22.6)	<0.001
Units/patient transfused^c	3 (2–7)	2 (1–2.5)	0.002^d
Platelets	11 (28.2)	9 (17.0)	0.197
Units/patient transfused^c	2 (1–3)	2 (1–3)	0.812^d
Prothrombin Complex Concentrate	7 (18.0)	2 (3.8)	0.033^e
10³ units/patient treated^c	1.8 (1.2–2.4)	3 (2.4–3.6)	0.133^d
Fibrinogen	29 (74.4)	11 (20.8)	<0.001
g/patient treated^c	4 (2–6)	4 (2–4)	0.205^d
Recombinant Factor VII	3 (7.7)	0 (0.0)	0.073^e
mg/patient treated^c	7 (5–9)	0 (0–0)	NA
Tranexamic acid	7 (18.0)	1 (1.9)	0.009^e
g/patient treated^c	1.5 (1.0–2.0)	1.0 (1.0–1.0)	0.368^d

Data given as number (percentage) unless otherwise indicated. Chi-squared tests were used for statistical tests unless otherwise indicated;
^aData given as mean (standard deviation)
^bstudent t test
^cdata given as median (range)
^dWilcoxon rank-sum test
^eFisher exact test

ISSN: 1471-2253