Effects of lung protective mechanical ventilation associated with permissive respiratory acidosis on regional extra-pulmonary blood flow in experimental ARDS

Table 1 Ventilation and gas exchange variables

	Increased P_AW	Limited P_AW
FiO₂, %	66 ± 25	84 ± 21	n.s.
Positive end-expiratory pressure, cm H₂O	5 ± 0	5 ± 0	n.s.
Peak inspiratory pressure, cm H₂O	23 ± 6	17 ± 4	p < 0.001
Mean airway pressure, cm H₂O	14.8 ± 2.6	11.4 ± 1.8	p < 0.001
V_T, mL. kg⁻¹	9.5 ± 3.0	6.2 ± 2.9	p < 0.001
Minute ventilation, L. min⁻¹	4.9 ± 0.8	3.4 ± 1.2	p < 0.001
Respiratory rate, min⁻¹	31 ± 2	34 ± 3	n.s.
PaO₂ / FiO₂, mm Hg	231 ± 104	182 ± 90	p < 0.05
PaCO₂, mm Hg	46 ± 12	71 ± 9	p < 0.001
pH_a	7.38 ± 0.04	7.27 ± 0.05	p < 0.001

P _AW airway pressure, FiO ₂ inspiratory fraction of oxygen, V _T tidal volume. Values are presented as mean ± standard deviation (SD); tested on a randomized basis; student t-test

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