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Fig. 2 | BMC Anesthesiology

Fig. 2

From: Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model

Fig. 2

a Western blotting of Nav1.7 using the total protein from ipsilateral L4-L6 DRGs of SMIR surgery rats, statistical summaries of western blot analysis: The expression of Nav1.7 protein was increased on days 10,15 and 20 after SMIR surgery (*P < 0.05,**P < 0.01, ***P < 0.001 vs naive group; n = 3). b-c Effect of pretreatment with i.t injection of ProTx-II (once daily from 1d before surgery until 7d after surgery) on the mechanical hyperalgesia induced by SMIR model rats. The result showed that selective Nav1.7 channel blocker can significantly reduced hyperalgesia induced by SMIR in a dose dependent way (*P < 0.05, ***P < 0.001 vs SMIR group; n = 6)

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BMC Anesthesiology

ISSN: 1471-2253

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