Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock

Table 1 (Comparison of variables and parameters at different time points)

	Baseline	Shock	Resuscitated	P Value
	Baseline	Shock	Resuscitated	Baseline versus Shock	Shock versus Resuscitated	Baseline versus Resuscitated
Heart Rate (bpm)	115 (111–140)	161 (141–176)	149 (133–177)	0.012	0.263	0.050
AP (mmHg)	95 (91–108)	43 (39–45)	70 (69–71)	0.012	0.012	0.012
CO (ml·min⁻¹·kg⁻¹)	112 (104–142)	62 (51–73)	130 (125–138)	0.012	0.012	0.401
CVP (mmHg)	2 (0–6)	1 (0–4)	6 (3–7)	0.050	0.012	0.017
PWP (mmHg)	8 (5–11)	6 (5–9)	11 (8–4)	0.036	0.012	0.017
R (mmHg·min·kg·ml⁻¹)	0.88 (0.69–1.00)	0.74 (0.55–0.78)	0.51 (0.46–0.51)	0.263	0.012	0.017
V (ml·kg⁻¹)	22 (17–38)	11 (10–22)	37 (29–39)	0.012	0.012	0.025
S (ml·min⁻¹·kg⁻¹)	52 (38–55)	27 (18–31)	43 (39–48)	0.012	0.012	0.208
Blood lactate (mmol·L⁻¹)	1.8 (1.6–1.9)	3.0 (2.5–3.5)	3.2 (2.4–4.3)	0.012	0.735	0.012
Ht (%)	30 (29–31)	43 (42–45)	38 (35–45)	0.012	0.263	0.069
SaO2 (%)	99 (99–100)	98 (95–98)	98 (97–99)	0.012	0.401	0.012
SvO2 (%)	85 (83–87)	72 (67–76)	82 (77–86)	0.068	0.068	1.000

Values are median (interquartile range). AP mean arterial pressure, CO cardiac output, CVP central venous pressure, PWP pulmonary wedge pressure, R systemic arterial resistance, V stressed blood volume, S Frank-Starling slope of the left ventricle, Ht hematocrit, SaO ₂ arterial oxygen saturation, SvO ₂ mixed venous oxygen saturation. (n = 8 for each time point, except for SvO₂ with n = 4 for each time point)

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