Fig. 6
From: Systemic LPS resulted in a transient hippocampus malfunction but a prolonged corpus callosum injury
Microglia activation state evaluated by proportional area measurement of positive Iba-1 labeling. a, one-way ANOVA analysis of proportional area from hippocampus of saline and systemic LPS groups at both day 3 and day 6 showed that LPS injections significantly enhanced microglial area (p < 0.01, **) compared to saline control; further, microglial area decreased at day 6 compared to that at day 3. b, analysis of proportional area from CC of both groups at both day 3 and day 6 displayed that system LPS significantly enhanced microglial area (p < 0.01, by ANOVA) versus saline control; while, microglial area further increased at day 6 compared to that at day 3, and microglial area was still significantly higher than that in the saline group (p < 0.01, by ANOVA). c, comparison of proportional area after system LPS between hippocampus and CC at day 3 showed no significant difference (by t-test). d, however, proportional area in the CC post system LPS but 3-day after ending of system LPS was significantly higher than that values in the hippocampus (p < 0.05, shown as ϯ, by t-test)