Table 3 Systemic and cerebral hemodynamic parameters and blood gas values measured in septic animals
Time point of measurement | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Parameters | TR n = 10 | T60 n = 10 | T120 n = 10 | T180 n = 7 | T240 n = 7 | T300 n = 4 | T360 n = 3 | T420 n = 2 | p–value |
BP Sys (mmHg) | 124.0 (119.0–140.0) | 125.5 (105.0–130.0) | 125.0 (77.0–143.2) | 126.0 (110.5–137.0) | 106.0 (86.0–113.0) | 76.0 (70.2–114.5) | 82.0 (65.5–118.0) | 80.0 (72.5–116.0) | <0.001 |
BP diast (mmHg) | 91.0 (85.0–100.0) | 92.0 (70.0–100.0) | 95.0 (56.0–111.5) | 98.0 (78.5–108.5) | 75.5 (63.0–90.0) | 54.0 (49.2–84.5) | 55.0 (46.7–91.7) | 54.0 (43.5–90.7) | <0.001 |
MAP (mmHg) | 102.3 (96.3–113.3) | 103.2 (81.7–115.0) | 105.0 (62.8–122.0) | 107.5 (89.2–118.8) | 85.6 (70.6–97.7) | 60.6 (56.4–94.5) | 64.0 (53.0–100.5) | 62.7 (53.2–99.2) | <0.001 |
Pulse rate (1/min) | 86.0 (77.0–95.0) | 86.5 (80.0–96.0) | 96.0 (79.7–98.5) | 107.0 (92.0–139.5) | 110.5 (102.0–125.0) | 105.0 (84.5–122.7) | 134.0 (111.5–162.5) | 135.0 (110.2–140.2) | <0.001 |
PaO2 (mmHg) | 89.5 (84.0–97.0) | 86.0 (79.7–101.7) | 71.0 (58.0–86.7) | 70.0 (65.0–97) | 78.0 (56.5–122.0) | 87.5 (50.0–125.0) | 118.0 (91.0–145.0) | 55.0 (49.0–62.5) | 0.18 |
PaCO2 (mmHg) | 43.5 (40.0–46.0) | 43.0 (35.2–43.2) | 43.0 (36.7–45.0) | 43.0 (38.0–46.2) | 42.0 (38.0–50.0) | 45.5 (41.0–50.0) | 47.5 39.0–56.0) | 48.0 (38.2–56.0) | 0.72 |
pH | 7.44 (7.43–7.45) | 7.42 (7.39–7.48) | 7.38 (7.36–7.43) | 7.36 (7.31–7.39) | 7.3 (7.22–7.37) | 7.3 (7.24–7.36) | 7.16 (7.13–7.2) | 7.22 (7.17–7.32) | <0.001 |
CI (l/min/m2) | 2.3 (1.8–3.0) | 2.3 (1.8–3.3) | 2.0 (1.6–2.6) | 1.7 (1.5–2.3) | 2.7 (1.7–3.1) | 1.7 (1.1–1.7) | 1.1 (1.0–1.7) | 1.6 (1.3–1.8) | <0.001 |
SVRI (dyn.sec.cm–5. m2) | 2658 (2139–3301) | 3315 (2405–4122) | 3331 (2729–4139) | 4150 (3499–4504) | 3254 (2061–5990) | 4529 (4201–5254) | 5687 (4724–5795) | 4585 (1654–5519) | 0.01 |
GEDI (ml/m2) | 415.0 (336.0–636.0) | 460.5 (387.5–646.0) | 393.5 (317–561.5) | 373.0 (227.2–534.0) | 373.0 (222.2–403.7) | 332.5 (219.0–474.0) | 223.0(166.0–453.2) | 254.0 (167.0–461.0 | 0.326 |
SVV (%) | 10.0 (7.0–13.0) | 8.0 (7.0–11.5) | 11.0 (9.5–12.7) | 17.0 (10.5–21.5) | 14.0 (9.5–15.5) | 20.5 (10.0–26.0) | 18.0 (14.2–23.2) | 14.0 (14.0–22.2) | 0.017 |
GEF (%) | 26.5 (22.0–28.0) | 21.0 (20.0–26.2) | 25.0 (19.0–27.0) | 17.5 (14.5–25.0) | 20.0 (17.7–21.5) | 17.5 (12.0–20.0) | 13.0 (10.7–17.5) | 19.0 (14.5–21.5) | <0.001 |
EVLWI (ml/kg) | 12.0 (10.0–17.0) | 15.5 (11.0–23.0) | 10.0 (8.2–18.0) | 15.5 (7.0–23.5) | 10.5 (6.0–15.0) | 15.0 (7.0–22.0) | 14.0 (8.0–26.0) | 20.0 (8.7–27.5) | 0.02 |
TCD systolic (cm/s) | 32.0 (26.0–36.0) | 33.5 (31.0–38.0) | 38.0 (29.7–39.5) | 32.5 (27.5–35.5) | 38.0 (24.5–43.7) | 29.0 (28.0–37.5) | 26.6 (24.5–39.0) | 29.0 (23.7–40.2) | 0.933 |
TCD diastolic (cm/s) | 18.5 (14.0–20.0) | 17.5 (17.0–21.0) | 18.0 (10.7–19.0) | 12.5 (9.0–15.0) | 11.0 (9.0–18.7) | 9.0 (8.0–12.5) | 6.0 (5.0–9.5) | 6.0 (6.0–12.7) | <0.001 |
TCD mean (cm/s) | 23.0 (17.0–24.0) | 23.0 (21.0–28.0) | 23.0 (18.2–26.5) | 17.5 (17.0–21.0) | 18.0 (15.0–28.2) | 18.0 (15.0–18.0) | 15.0 (11.5–19.5) | 19.0 (13.0–19.7) | 0.117 |
TCD PI | 0.64 (0.55–0.67) | 0.67 (0.57–0.78) | 0.9 (0.62–1.0) | 0.9 (0.86–1.4) | 0.95 (0.86–1.15) | 1.2 (1.07–1.58) | 1.7 (1.16–2.0) | 1.4 (0.88–1.88) | <0.001 |