Table 2 Systemic and cerebral hemodynamic parameters and blood gas values measured in control animals
Time point of measurement | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Parameters | TR | T60 | T120 | T180 | T240 | T300 | T360 | T420 | p–value |
BP Sys (mmHg) | 120 (116–134.2) | 117 (109–7–130.2) | 120 (93.7–130.5) | 123 (103–130.7) | 119 (98.2–125.7) | 118 (116.5–130) | 130 (123.3–133.7) | 118 (118–130) | 0.09 |
BP diast (mmHg) | 92 (89.5–99.2) | 89 (84.7–93.2) | 89 (84.7–93.2) | 94 (82.2–97.0) | 86 (81.5–91.5) | 80.5 (64–96.5) | 84.0 (77.2–85.5) | 86 (83.0–87.5) | 0.007 |
MAP (mmHg) | 100 (96.2–108.1) | 102 (90.7–105.8) | 96 (90–108.5) | 98 (84.2–102.5) | 94 (82.2–105.7) | 94.6 (90.6–100.2) | 98.0 (97.2–102.2) | 94 (91–100.5) | 0.09 |
Pulse rate (1/min) | 89 (72.2–94) | 89 (73.2–95) | 86 (79–98) | 88 (77.2–96.2) | 83.5 (78–92) | 82 (79–90.2) | 92 (84.5–93.5) | 82 (81.2–85) | 0.15 |
PaO2 (mmHg) | 82 (77.5–92.7) | 100 (83–113.5) | 89 (76–114) | 92 (81.5–100.2) | 82 (74.7–89.7) | 81 (77.2–106.5) | 79 (75.2–99.2) | 76 (76–77.1) | 0.3 |
PaCO2 (mmHg) | 43 (41.2–48.2) | 38 (25.7–44) | 40 (30.5–45.2) | 42 (29–44.5) | 45 (39–48.2) | 38 (32–47) | 35 (29–47) | 43.5 (39–48) | 0.07 |
pH | 7.44 (7.41–7.45) | 7.43 (7.41–7.55) | 7.43 (7.39–7.52) | 7.42 (7.38–7.45) | 7.38 (7.36–7.43) | 7.41 (7.35–7.44) | 7.43 (7.36–7.46) | 7.36 (7.34–7.38) | 0.15 |
CI (l/min/m2) | 2.2 (1.9–3.1) | 2.5 (1.9–2.9) | 2.2 (1.3–2.8) | 2.1 (1.6–2.6) | 2.2 (1.8–2.7) | 2.2 (1.5–2.7) | 1.8 (1.5–2.3) | 2.1 (1.6–2.2) | 0.08 |
SVRI (dyn.sec.cm−5. m2) | 2823 (2478–3849) | 2990 (2550–3916) | 3227 (2731–4427) | 3182 (2580–4677) | 3088 (2813–4337) | 3909 (3264–5328) | 4340 (3626–4640) | 3705 (3669–4387) | 0.37 |
GEDI (ml/m2) | 428 (346–470) | 426 (342–524) | 448 (329–480) | 428 (346–470) | 459 (358–482) | 402 (334–499) | 373 (244–388) | 350 (230–381) | 0.77 |
SVV (%) | 13 (10.3–14.3) | 14 (11–15) | 19 (12.7–20.7) | 15 (13.3–18.3) | 17.5 (13–19) | 19 (13.3–20.7) | 15 (14.7–16.5) | 18 (12.7–18) | 0.27 |
GEF (%) | 28 (23–33.5) | 27 (22.5–31.5) | 25 (21.7–28.7) | 24.5 (22–27.5) | 24.5– (23.5–26) | 29 (24.7–29.3) | 27 (24.7–28.2) | 27 (25.5–27.3) | 0.16 |
EVLWI (ml/kg) | 15 (9.7–16.7) | 14 (9.5–17.5) | 16 (11–18.7) | 17.5 (11.5–20.5) | 15 (9–16.8) | 12 (8.3–15.8) | 13 (8.5–16) | 13 (8.5–16.8) | 0.22 |
TCD systolic (cm/s) | 27 (26–36.5) | 28 (26–36.5) | 30 (23–39.2) | 28 (23.7–35.5) | 30 (24.5–33) | 40 (33.2–45.2) | 33 (33–34.5) | 36 (34.5–36) | 0.89 |
TCD diastolic (cm/s) | 14 (11.7–16.2) | 13 (10.5–16) | 12 (10–17.7) | 11 (10–16) | 13 (9.7–14.7) | 15 (11.2–18.2) | 15 (13.5–15.2) | 15 (12.7–21.2) | 0.91 |
TCD mean (cm/s) | 20 (17.2–23.2) | 18 (16–20.5) | 19 (16–24.5) | 17 (15–21) | 19 (15–20.8) | 25 (19.7–28.7) | 21 (20.2–21.7) | 21 (21–25.5) | 0.89 |
TCD PI | 0.67 (0.64–0.78) | 0.83 (0.71–0.88) | 0.91 (0.63–1.09) | 0.93 (0.67–1.03) | 0.9 (0.73–1.02) | 0.93 (0.85–1.01) | 0.92 (0.87–0.93) | 0.89 (0.61–0.99) | 0.15 |