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Table 2 Cytokines

From: Does local infiltration analgesia reduce peri-operative inflammation following total hip arthroplasty? A randomized, double-blind study

 

Pre-operative

4 h postoperative

3 days postoperative

LIA (N:28)

FNB (N:26)

LIA (N:28)

FNB (N:26)

FNB vs. LIA

Mean ratio (95% CI)

P-Value

LIA (N:29)

FNB (N:26)

FNB vs. LIA

Mean ratio (95% CI)

P-Value

IL-6 pg/ml

1.0 (0.6–1.6)

1.3 (0.6–1.8)

17.2 (15.4–23.2)

23.5 (18.3–27.9)

1.26 (1.08–1.49)

0.015

12.6 (7.6–16.4)

10.3 (7.3–18.5)

0.89 (0.59–1.34)

NS

IL-10 pg/ml

3.2 (2.4–3.6)

3.0 (2.5–3.4)

3.7 (3.2–4.4)

3.7 (3.1–4.6)

1.10 (0.95–1.28)

NS

3.4 (2.6–4.0)

3.2 (2.6–3.6)

0.96 (0.90–1.02)

NS

TNF-α pg/ml

5.3 (3.7–6.5)

4.9 (3.3–7.7)

5.4 (2.9–7.3)

4.2 (2.9–5.5)

0.79 (0.61–1.03)

NS

3.6 (2.4–5.8)

3.5 (2.2–8.4)

1.08 (0.74–1.56)

NS

IL-1Rα pg/ml

50.2 (9.7–95.5)

30.2 (6.7–99.9)

96.1 (52.1–282.2)

93.6 (45.3–180.1)

1.01 (0.61–1.66)

NS

96.0 (58.5–134.9)

110.7 (49.0–170.7)

1.19 (0.69–2.06)

NS

IL-1β pg/ml

5.7 (4.1–7.6)

5.6 (3.2–7.4)

3.9 (2.1–6.7)

3.4 (2.6–4.6)

0.95 (0.72–1.26)

NS

3.6 (1.6–5.3)

3.8 (2.2–6.4)

1.36 (0.97–1.92)

NS

IL-2 pg/ml

5.8 (3.2–7.9)

6.4 (2.7–9.4)

4.9 (2.8–8.2)

3.2 (2.1–6.1)

0.89 (0.02–1.73)

NS

3.4 (1.0–6.3)

2.9 (1.6–9.7)

1.31 (0.77–2.22)

NS

IL-2R pg/ml

31.6 (8.8–66.5)

29.7 (20.5–49.2)

42.0 (21.8–61.8)

42.6 (31.2–53.5)

1.03 (0.80–1.32)

NS

46.3 (25.6–85.8)

44.8 (25.7–79.1)

0.90 (0.69–1.16)

NS

IL-4 pg/ml

15.6 (6.9–25.2)

12.2 (4.7–26.3)

10.6 (0.5–17.1)

6.0 (0.5–14.5)

0.77 (0.35–1.67)

NS

0.5 (0.5–15.0)

7.0 (0.5–23.0)

1.37 (0.61–3.07)

NS

IL-5 pg/ml

6.5 (4.3–9.7)

4.6 (3.2–7.1)

5.2 (2.1–7.4)

3.6 (2.5–4.4)

0.88 (0.68–1.15)

NS

4.2 (1.7–6.4)

3.8 (2.6–5.8)

1.30 (0.95–1.78)

NS

IL-8 pg/ml

1.1 (0.5–3.1)

2.2 (0.6–4.3)

6.4 (4.7–10.9)

4.2 (2.3–7.2)

0.30 (0.08–1.16)

NS

2.6 (1.2–3.7)

2.0 (0.8–4.1)

0.86 (0.24–3.09)

NS

IL-12 pg/ml

47.4 (35.4–62.9)

53.6 (37.1–77.6)

46.6 (35.3–64.4)

46.5 (32.5–71.9)

0.91 (0.83–1.00)

NS

50.4 (41.4–69.7)

56.5 (34.4–80.2)

0.89 (0.80–1.00)

NS

IFN-γ pg/ml

0.9 (0.3–1.7)

0.8 (0.2–2.3)

1.6 (0.9–2.4)

1.6 (0.9–3.2)

1.23 (0.93–1.61)

NS

0.9 (0.5–2.0)

0.9 (0.4–2.8)

1.17 (0.89–1.53)

NS

  1. Results of cytokines are shown as median (25th-75th percentile) and mean ratios (95% CI) evaluated on log scale by linear mixed model between study Group C and Group LIA at 4 h and 3 days postoperatively adjusted for pre-operatively measures. P-values for the three study primary outcomes were corrected for multiple comparison with Bonferroni-Holm method. P-values for the nine secondary outcomes were corrected with the same method
  2. NS non-significant, CI confidence interval, N number of patients, Group LIA local infiltration analgesia, Group C Control Group (Femoral nerve block)