Dexmedetomidine’s inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation

Table 1 Dexmedetomidine concentration

Added in organ bath buffer (μM)	1	10	100
Tracheal ring tissue, Mean ± SEM (nM)	0.54 ± 0.082	3.6 ± 0.39	26 ± 3.9

Table 1 tissue concentrations of dexmedetomidine in guinea pig tracheal rings (n = 5 animals). Guinea pig tracheal rings were incubated for 30 mins in buffer with 1–100 μM dexmedetomidine. Following extraction, average penetrating tissue concentrations of dexmedetomidine were deteremined by HPLC – MS/MS

ISSN: 1471-2253