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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Dexmedetomidine’s inhibitory effects on acetylcholine release from cholinergic nerves in guinea pig trachea: a mechanism that accounts for its clinical benefit during airway irritation

Fig. 1

Guinea pig tracheal ring muscle force generated in response to cholinergic electrical field stimulation (EFS). a Following stable EFS-induced contractions, 100 μM of dexmedetomidine, 10 μM remifentanil or 1 mM lidocaine or vehicle (0.1% DMSO) were added to buffer solution. Dexmedetomidine and lidocaine inhibited EFS-induced contractions. b, c Dexmedetomidine attenuates guinea pig tracheal ring muscle force generated in response to cholinergic EFS contraction. Representative trace of EFS-induced muscle force over time with increasing concentrations of dexmedetomidine (b) and expressed as percent change from the initial baseline EFS-induced contraction (c). Control tracheal rings treated with the vehicle DMSO (0.1%) serves as a time control. Mean ± SEM (n = 4). *p < 0.05

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BMC Anesthesiology

ISSN: 1471-2253

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