Effects of short-term hyperoxia on erythropoietin levels and microcirculation in critically Ill patients: a prospective observational pilot study

Table 2 Variations in erythropoietin, reticulocyte count, haemoglobin and haematocrit in the two groups

	Baseline	24 h	48 h	p (time)^a	p (interaction)^b
Erythropoietin (IU/L)					-
Hyperoxia	16.1 [7.4–20.2]	20.1 [10.7–31.2]	22.9 [14.1–37.2]^#	0.022
Controls	12.8 [7.3–22.2]	14.9 [9.2–18.6]	14.8 [7.9–24.8]	0.692
Reticulocytes (*10³/mm³)					-
Hyperoxia	55.9 [39.4–67.4]	47.3 [33.1–62.2]^##	46.2 [29.8–66.2]	0.010
Controls	60.2 [46.3–78.7]	52.5 [42.9–65.9]	50.7 [44.1–64.5]^#	0.027
Hemoglobin (g/dL)					0.601
Hyperoxia	10.7 ± 1.4	10.2 ± 1.3	10.1 ± 1.3^#	0.013
Controls	11.7 ± 2.0	11.3 ± 1.8	11.3 ± 1.7	0.027
Hematocrit (%)					0.053
Hyperoxia	32 ± 6	31 ± 6	30 ± 6^#*	0.029
Controls	34 ± 8	34 ± 8	34 ± 8	0.675

Data are expressed as mean ± standard deviation or median [1st-3rd quartile], as appropriate
^a Overall effect of time on the variance in each group. One-way ANOVA for repeated measures with Bonferroni’s post hoc test or Friedman test with Dunn’s test for multiple comparisons, as appropriate
^b Test of interaction between time and groups. Two-way ANOVA for repeated measures. This was applicable only to normally distributed variables
*p < 0.05 versus controls (same time point); two-way ANOVA for repeated measures with Bonferroni post-hoc test

ISSN: 1471-2253