Fig. 4
The effects of propfol, okadaic acid, FTY720 and KN93 on CoCl2-induced inhibition of cell viability, and the epression of PP2A, pCAMKIIα, pnNOS-Ser1412, pnNOS-Ser847 expression a, b, c and d CoCl2-induced BAX, PP2A and cleaved caspase 3 overexpression was attenuated by propofol. Bcl2 down-regulation by CoCl2 was reversed by propofol and okadaic acid. Besides PP2A, the effects of propofol could be reversed by FTY720 and KN93. e and f pCAMKIIα down-regulation by CoCl2 was reversed by propofol and okadaic acid. The effects of propofol could be reversed by FTY720 and KN93. g, h and i CoCl2-induced pnNOS-Ser1412 overexpression was attenuated by propofol and pnNOS-Ser847 down-regulation by CoCl2 was reversed by propofol and okadaic acid. The effects of propofol could be reversed by FTY720 and KN93. j propofol and okadaic acid attenuated CoCl2-induced cytotoxicity. The effects of propofol could be reversed by FTY720 and KN93. (* p < 0.05 vs. control, # p < 0.05 vs. CoCl2 treatement, n = 5, Data were shown as mean ± SD)