Targeting urine output and 30-day mortality in goal-directed therapy: a systematic review with meta-analysis and meta-regression

Table 4 Meta-regression model of sensitivity analysis with 30-day mortality for conventional and goal-directed fluid therapy

Variable	CFM	GDT
Targeting urine output	0.56 (0.29-1.11)	0.68 (0.34-1.36)
Intensive Care setting (reference)
Intraoperative setting	0.16 (0.08-0.30)	0.14 (0.08-0.24)
Postoperative setting	0.07 (0.03-0.16)	0.17 (0.05-0.57)
Transpulmonary thermodilution (reference)
Esophageal Doppler		0.61 (0.23-1.60)
Pulmonary artery catheter		1.80 (0.51-6.33)
Other monitoring devices		0.21 (0.07-0.63)
Other etiologies (reference)
Abdominal	0.48 (0.21-1.10)	1.14 (0.54-2.38)
High risk	2.36 (0.99-5.67)	1.19 (0.61-2.30)
Inotropic use	1.43 (0.67-3.07)	1.15 (0.47-2.81)
Publication year ^a	0.95 (0.9-1.00)	0.95 (0.88-1.03)

The sensitivity analysis excluded studies in which the urine output threshold was not 0.5 ml/kg/h
^aPublication year was inputted as the years from the mean publication year (2008). Data reported as odds ratio and 95% confidence interval

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