Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

BMC Anesthesiology

Table 5 Summary of pooled ORs in the meta-analysis of CD14 159C/T analyzing the effect of the CD14 polymorphism on sepsis-related mortality

Genetic Model	Pooled OR	95% CI		P	Chi-square	p^#	I²	P*	Statistical Power
Genetic Model	Pooled OR	Lower	Upper	P	Chi-square	p^#	I²	P*	Statistical Power
CD14-159C/T
Cvs T	0.97	0.68	1.40	0.88	32.94	<0.01	76%	0.164	0.314
CC vs TT	1.02	0.50	2.10	0.96	29.56	<0.01	73%	0.060	0.363
TC vs TT	1.17	0.67	2.03	0.59	21.97	<0.01	64%	0.877	0.520
CC + CT vs TT	1.08	0.59	1.97	0.79	29.44	<0.01	73%	0.695	0.525
CC vs CT + TT	0.96	0.61	1.50	0.84	20.01	0.01	60%	<0.01	0.074
CD14-159C/T in Asian population
C vs T	0.53	0.31	0.92	0.02	0.53	0.77	0%	0.432	0.650
CC vs TT	0.40	0.14	1.11	0.08	0.85	0.65	0%	0.229	0.513
TC vs TT	0.31	0.13	0.74	0.009	1.17	0.56	0%	0.849	0.688
CC + CT vs TT	0.34	0.16	0.74	0.007	0.71	0.70	0%	0.873	0.739
CC vs CT + TT	0.75	0.29	1.95	0.56	1.22	0.54	0%	0.005	0.163
CD14-159C/T in Caucasian population
C vs T	1.16	0.79	1.71	0.46	24.04	<0.01	79%	0.498	0.541
CC vs TT	1.37	0.62	3.04	0.44	22.36	<0.01	78%	0.392	0.631
TC vs TT	1.67	1.08	2.59	0.02	8.17	<0.01	39%	0.648	0.823
CC + CT vs TT	1.56	0.89	2.74	0.12	15.08	<0.01	67%	0.627	0.836
CC vs CT + TT	1.00	0.59	1.69	0.99	18.07	<0.01	72%	0.289	0.085
CD14-159C/T in Burn ICU
C vs T	0.84	0.26	2.73	0.77	8.27	0.02	76%	0.027	0.268
CC vs TT	0.74	0.07	8.30	0.81	6.74	0.03	70%	0.076	0.244
TC vs TT	0.99	0.30	3.30	0.98	0.21	0.90	37%	0.134	0.065
CC + CT vs TT	0.86	0.17	4.27	0.85	5.78	0.06	65%	0.206	0.126
CC vs CT + TT	0.96	0.20	4.67	0.96	4.12	0.13	51%	0.038	0.265

p^#: P-value for heterogeneity test. p*: P-value for Egger’s test; OR odds ratio; CI confidence interval

ISSN: 1471-2253