Association between the -159C/T polymorphism in the promoter region of the CD14 gene and sepsis: a meta-analysis

BMC Anesthesiology

Table 4 Summary of pooled ORs in the meta-analysis of CD14 159C/T analyzing the effect of the CD14 polymorphism on incidence of sepsis

Genetic Model	Pooled OR	95% CI		P	Chi-square	p^#	I²	P*	Statistical Power
Genetic Model	Pooled OR	Lower	Upper	P	Chi-square	p^#	I²	P*	Statistical Power
CD14-159C/T
C vs T	0.85	0.69	1.05	0.13	14.72	0.10	39%	0.048	0.155
CC vs TT	0.69	0.44	1.08	0.10	15.77	0.07	43%	0.022	0.134
TC vs TT	0.99	0.73	1.35	0.96	11.19	0.26	20%	0.024	0.102
CC + CT vs TT	0.88	0.64	1.22	0.44	13.57	0.14	34%	0.024	0.434
CC vs CT + TT	0.77	0.56	1.05	0.10	12.18	0.20	26%	0.008	0.337
CD14-159C/T in Asian population
C vs T	0.77	0.58	1.02	0.07	3.70	0.45	0%	0.181	0.520
CC vs TT	0.53	0.29	0.95	0.03	3.76	0.44	0%	0.110	0.701
TC vs TT	1.03	0.62	1.73	0.90	4.68	0.32	14%	0.236	0.092
CC + CT vs TT	0.84	0.50	1.42	0.52	5.07	0.28	21%	0.203	0.071
CC vs CT + TT	0.50	0.30	0.85	0.01	1.89	0.76	0%	0.134	0.884
CD14-260C/T in Caucasian population
C vs T	0.91	0.68	1.23	0.55	9.12	0.06	56%	0.387	0.050
CC vs TT	0.84	0.48	1.50	0.56	8.96	0.06	55%	0.32	0.050
TC vs TT	0.93	0.60	1.44	0.75	6.50	0.16	38%	0.035	0.067
CC + CT vs TT	0.88	0.55	1.40	0.59	8.33	0.08	52%	0.276	0.451
CC vs CT + TT	0.92	0.64	1.33	0.66	5.84	0.21	32%	0.800	0.060
CD14-159C/T in Burn ICU
C vs T	0.69	0.40	1.17	0.17	1.17	0.56	0%	0.218	0.290
CC vs TT	0.33	0.10	1.11	0.07	0.81	0.67	0%	0.386	0.517
TC vs TT	0.98	0.41	2.35	0.97	1.61	0.45	0%	0.023	0.050
CC + CT vs TT	0.80	0.35	1.83	0.60	1.75	0.42	0%	0.023	0.082
CC vs CT + TT	0.34	0.11	1.00	0.05	0.63	0.73	0%	0.786	0.435

p^#: P-value for heterogeneity test. p*: P-value for Egger’s test; OR odds ratio, CI confidence interval

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