Table 4 Subgroup analysis of individual neuromuscular blocking agents
From: Observational study on patterns of neuromuscular blockade reversal
Cases receiving neostigmine | Cases not receiving neostigmine | |||||||
|---|---|---|---|---|---|---|---|---|
Neuromuscular blocking agent | Cases receiving NMB | NMB total dose (ED 95 Equivalent)a | Time between last NMB & extubation (minutes) | Total dose of neostigmine (mcg/kg)b | Cases receiving NMB | NMB total dose (ED 95 Equivalent)a | Time between last NMB & extubation (minutes) | |
N | Median [IQR] | Median [IQR] | Median [IQR] | N | Median [IQR] | Median [IQR] | ||
No Succinylcholine | Atracurium | 2981 | 3.9 [2.6, 5.9] | 67.0 [50.0, 90.0] | 33.7 [29.7, 41.7] | 906 | 2.9 [2.1, 4.7] | 119.0 [85.0, 174.0] |
Cisatracurium | 12,905 | 5.6 [3.9, 8.3] | 73.0 [53.0, 102.0] | 36.0 [30.2, 42.4] | 2596 | 4.6 [3.1, 7.1] | 136.0 [90.0, 204.0] | |
Pancuronium | 134 | 1.3 [0.1, 2.3] | 99.5 [62.0, 161.0] | 47.2 [35.8, 61.7] | 48 | 0.1 [0.1, 0.1] | 210.5 [150.5, 265.0] | |
Rocuronium | 5602 | 2.8 [2.2, 4.0] | 83.0 [59.0, 117.0] | 36.6 [29.8, 41.7] | 1510 | 2.4 [1.8, 3.4] | 126.0 [89.0, 174.0] | |
Vecuronium | 65,708 | 3.4 [2.4, 4.9] | 76.0 [55.0, 108.0] | 38.2 [31.5, 42.2] | 7343 | 2.8 [2.0, 4.5] | 145.0 [93.0, 233.0] | |
Multiple NMBAs | 1185 | 5.9 [4.4, 8.0] | 71.0 [52.0, 101.0] | 39.0 [32.1, 44.9] | 216 | 6.6 [4.8, 8.6] | 92.0 [37.5, 162.5] | |
Succinylcholine | Atracurium | 1407 | 3.4 [2.2, 5.4] | 60.0 [46.0, 84.0] | 31.8 [28.2, 39.0] | 439 | 2.5 [1.5, 4.4] | 95.0 [65.0, 141.0] |
Cisatracurium | 4591 | 4.8 [2.9, 7.6] | 65.0 [49.0, 88.0] | 32.7 [28.8, 40.0] | 864 | 4.1 [2.2, 7.5] | 106.0 [68.0, 153.0] | |
Pancuronium | 63 | 2.1 [1.2, 2.6] | 96.0 [74.0, 140.0] | 37.0 [31.6, 48.0] | 1025 | 0.1 [0.1, 0.1] | 101.5 [60.0, 181.5] | |
Rocuronium | 674 | 2.1 [1.3, 3.0] | 62.0 [42.0, 87.0] | 32.1 [26.1, 39.4] | 232 | 1.0 [0.3, 2.0] | 81.0 [53.0, 129.0] | |
Vecuronium | 21,514 | 3.0 [1.9, 4.7] | 67.0 [49.0, 93.0] | 36.7 [30.0, 41.3] | 3026 | 2.6 [1.3, 4.8] | 115.0 [67.0, 195.0] | |
Multiple NMBAs | 359 | 3.6 [2.2, 5.6] | 65.0 [46.0, 94.0] | 35.1 [30.0, 41.3] | 305 | 3.0 [1.5, 6.3] | 82.0 [41.0, 154.0] | |