Table 2 Oxygen transport and tissue oxygenation
From: Influence of clonidine induced sympathicolysis on anaemia tolerance in anaesthetized pigs
Group | BL1 | BL2 | 25 % | 50 % | 75 % | Hbcrit | |
|---|---|---|---|---|---|---|---|
Hb | Saline | 9,0 (8,9–9,3) | 8,6 (8,5–9,2) | 6,0 (5,6–6,4)** | 4,3 (3,9–4,5) | 3,0 (2,7–3,1) | 2,2 (2–2,5) |
g dl−1 | Clonidine | 8,7 (8,5–9) | 8,7 (8,4–8,9) | 6,5 (6,1–6,7)** | 4,2 (4,1–4,7) | 3,1 (2,9–3,4) | 2,1 (2,1–2,4) |
paO2 | Saline | 90 (89–102) | 89 (88–91) | 93 (84–95) | 93 (92–97) | 94 (88–98) | 108 (93–113) |
mmHg | Clonidine | 92 (85–101) | 94 (90–109) | 85 (81–101) | 93 (80–104) | 93 (81–102) | 109 (94–122) |
pvO2 | Saline | 36 (36–38) | 37 (36–44)** | 41 (36–44) | 35 (32–37) | 36 (33–42) | 26 (22–28) |
mmHg | Clonidine | 43 (41–45) | 27 (26–32)** | 32 (31–36) | 36 (33–40) | 29 (28–31) | 26 (24–32) |
CaO2 | Saline | 12,2 (12–12,5) | 11,6 (11,5–12,3) | 8,3 (7,7–8,6)** | 6,1 (5,4–6,2) | 4,2 (3,8–4,5) | 3,3 (3–3,6) |
ml dl−1 | Clonidine | 11,8 (11,5–12,2) | 11,8 (11,5–11,9) | 8,9 (8,3–9,1)** | 5,9 (5,7–6,4) | 4,4 (4,1–4,8) | 3,2 (3,1–3,4) |
avDO2 | Saline | 3,9 (3,2–4,8) | 3,4 (3,1–4,6)** | 2,4 (1,8–3,2) | 2,3 (1,9–2,8) | 2,0 (1,9–2,2) | 1,9 (1,7–2,1) |
ml dl−1 | Clonidine | 4,7 (4,2–5,0) | 6,3 (5,6–7,5)** | 3,4 (2,5–4,0) | 2,8 (2,3–2,8) | 2,1 (1,4–2,1) | 1,4 (1,1–1,9) |
O2-ER | Saline | 31,3 (25,3–39,3) | 29,7 (26,2–38,3)** | 31,8 (23,6–41,5) | 40,3 (37–46,4) | 49,3 (48,1–49,9) | 56,7 (54,1–58,2) |
% | Clonidine | 41,2 (34,8–43,7) | 58,5 (47,5–63,4)** | 41,3 (31,3–44,2) | 47,5 (37,4–48,2) | 49,0 (28,5–50,7) | 44,7 (34,2–49,1) |
SaO2 | Saline | 98,7 (97,9–99,1) | 98,5 (98,4–98,7) | 98,7 (97,9–99,0) | 99,0 (98,7–99,3) | 99,1 (98,7–99,2) | 99,3 (99,0–99,5) |
% | Clonidine | 98,6 (98,1–99,0) | 98,6 (98,0–99,1) | 98,3 (98,3–98,7) | 98,6 (98,0–98,9) | 98,9 (98,2–99,0) | 99,1 (98,9–99,1) |
SvO2 | Saline | 68,4 (59,4–75,5) | 70,0 (61,8–73,5)** | 69,1 (59–76,6) | 61,9 (55,4–64,4) | 52,2 (51,5–53,4) | 45,5 (44,3–48,3) |
% | Clonidine | 57,8 (56,1–65,0) | 41,7 (35,8–51,3)** | 60,2 (55,7–68,9) | 53,2 (53,2–63,5) | 52,8 (50,3–71,0) | 57,1 (55,5–70,0) |
DO2i | Saline | 607 (569–623) | 636 (612–677)** | 512 (455–542)** | 430 (393–469)** | 300 (284–348) | 313 (266–336) |
ml min−1 m−2 | Clonidine | 512 (503–565) | 269 (261–387)** | 342 (288–418)** | 281 (258–382)** | 283 (228–394) | 236 (190–341) |
VO2im | Saline | 187 (180–196) | 190 (183–197)** | 185 (183–197)** | 179 (170–196) | 179 (175–193) | 162 (153–181)** |
ml min−1m−2 | Clonidine | 175 (161–193) | 145 (140–159)** | 181 (168–187)** | 183 (174–199) | 175 (161–179) | 130 (122–157)** |
VO2ic | Saline | 209 (188–247) | 231 (131–259) | 152 (118–211) | 162 (144–198) | 161 (147–178) | 169 (157–201)** |
ml min−1m−2 | Clonidine | 205 (142–223) | 171 (129–236) | 146 (102–157) | 132 (88–146) | 123 (94–166) | 91 (53–158)** |
Lactate | Saline | 1,3 (1,2–1,5) | 1,3 (1,1–1,6) | 1,2 (1–1,4) | 1,1 (0,9–1,2) | 1,1 (1–1,1) | 1,6 (1,3–1,9) |
mmol l−1 | Clonidine | 1,3 (1–1,5) | 1,6 (1,2–1,6) | 1,2 (0,9–1,4) | 1,0 (0,8–1,2) | 0,9 (0,8–1,2) | 1,9 (1,4–2,1) |