Early prediction of acute kidney injury after transapical and transaortic aortic valve implantation with urinary G1 cell cycle arrest biomarkers

Table 2 Analysis of applying best and previously published cutoff points of urinary [TIMP 2]*[IGFBP7] for the prediction of AKI KDIGO 2/3

	AUC	Cut-Off	Sensitivity	Specificity	Youden’s index
4 h after surgery	0.646	0.185	0.75	0.56	0.31
		0.3	0.38	0.67	0.05
		2.0	0.13	1.0	0.13
Day 1 after surgery	0.971	1.0	1.0	0.9	0.9
		0.3	1.0	0.55	0.55
		2.0	0.67	0.95	0.62
Maximum early value^a	0.869	0.91	0.88	0.83	0.71
		0.3	0.88	0.48	0.36
		2.0	0.5	0.93	0.43

AKI acute kidney injury, AUC Area under the curve, IGFBP7 insulin-like growth factor binding protein 7, KDIGO Kidney Disease: Improving Global Outcomes, RRT renal replacement therapy, TIMP-2 tissue metalloproteinase 2
^adefined as maximum level in the first 24 h after surgery

ISSN: 1471-2253