Fig. 2
From: Anti-nerve growth factor antibody attenuates chronic morphine treatment-induced tolerance in the rat
Effects of anti-NGF antibody on the development of morphine-induced tolerance (OIT). a. Hind paw withdrawal latency to thermal stimulation expressed as percentage of maximal possible effect (% MPAE) decreased in rats that received chronic morphine treatment (10 mg/kg, s.c.) on days 3 and 5. Co-administration of morphine with anti-NGF (10 μg, i.p.) significantly reduced the decreased withdrawal latency on days 3 and 5. Each data point represents the mean ± S. E. M. of six rats per group. ***P < 0.001 compared with either Morphine-Saline group or Anti-NGF-Saline; ###P < 0.001 compared Saline-Saline group or Anti-NGF-Saline group; $ P < 0.05 compared to Morphine-Saline group. b. Area under the curve (AUC) from 0 to 120 h, *P < 0.01 compared to Saline-Saline group, ***P < 0.0001 compared to Saline-Saline or Anti-NGF-Saline and Morphine-Saline groups