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Table 3 Results of subgroup analysis

From: Anion gap as a prognostic tool for risk stratification in critically ill patients – a systematic review and meta-analysis

Study characteristic Groups Studies (nr) Total sample size Pooled AUC (95 % CIs) I2 test P-value
Study setting Trauma patients 9, 10, 15 787 0.83 (0.68, 0.99) 97 % 0.0235
ICU patients 4, 5, 12, 16, 17 1474 0.66 (0.59, 0.73) 69 %
Age Mean/Median age 30–40 years 5, 9, 10, 15 1055 0.81 (0.69, 0.93) 97 % 0.0114
Mean/Median age 60–70 years 4, 8, 12, 16, 17 1878 0.66 (0.60, 0.71) 70 %
Intravenous fluids restriction Restriction 9, 10 356 0.91 (0.8, 1.0) 95 % 0.0008
No restriction 4, 5, 8, 12, 15, 16, 17 2573 0.67 (0.62, 0.72) 68 %
Intravenous fluids restriction and AG measured before treatment initiation Restriction and AG measurement before hospital treatment initiation 5, 8, 9, 10 1296 0.83 (0.73, 0.93) 98 % <0.0001
No restriction or AG measured after treatment was commenced 4, 12, 15, 16, 17 1633 0.63 (0.60, 0.66) 0 %
Routine use of gelatin-based intravenous fluids in study country Gelatins not routinely used 12, 15 1091 0.62 (0.58, 0.65) 0 % 0.3344
Gelatins routinely used 4, 16, 17 542 0.65 (0.6, 0.7) 0 %
Outcome measure Time frame stated e.g. 31-day or 28-day mortality 4, 9, 10, 12, 16 1266 0.74 (0.52, 0.96) 99 % 0.6518
In-hospital mortality 8, 15, 17 1399 0.69 (0.64, 0.75) 44 %
Overall mortality in study population Below 30 % 5, 8, 9, 12, 15, 17 2613 0.74 (0.55, 0.93) 99 % 0.8856
Above 30 % 4, 10, 16 320 0.70 (0.57, 0.84) 83 %
Date of publication Before and including 2005 4, 5, 8, 9, 15 1710 0.76 (0.59, 0.94) 98 % 0.4325
2006 and after 10, 12, 16, 17 1184 0.67 (0.58, 0.77) 87 %
  1. CIs confidence intervals, ICU intensive care unit