Comparison of pressure-controlled ventilation with volume-controlled ventilation during one-lung ventilation: a systematic review and meta-analysis

Table 2 Sensitivity analysis of crossover study and abstract on the meta-analysis

Outcome		Studies (n)	Patients (n)	WMD	95 % CI	I² (%)	P value
PaO₂/FiO₂ ratio	Total	6 [18, 21, 26–29]	259	11.04 mmHg	0.30 to 21.77	3	0.04
	Crossover studies	5 [18, 21, 27–29]	204	12.84 mmHg	1.21 to 24.47	12	0.03
	Non-crossover studies	1 [26]	55	0.70 mmHg	−27.15 to 28.55	0	0.96
PaCO₂	Total	5 [18, 21, 26, 28, 29]	229	−0.28 mmHg	−1.14 to 0.58	0	0.52
	Crossover studies	4 [18, 21, 28, 29]	174	−0.32 mmHg	−1.22 to 0.58	0	0.49
	Non-crossover studies	1 [26]	55	0.10 mmHg	−2.71 to 2.91	65	0.94
Peak inspiratory Pressure	Total	6 [18, 21, 26–29]	259	−4.91cmH₂O	−7.30 to −2.53	91	<0.0001
	Crossover studies	5 [18, 21, 27–29]	204	−5.27cmH₂O	−7.98 to −2.57	92	<0.0001
	Non-crossover studies	1 [26]	55	−3.10cmH₂O	−4.79 to −1.41	0	<0.0001
Plateau inspiratory Pressure	Total	5 [18, 21, 26, 28, 29]	229	−1.13cmH₂O	−2.54 to 0.28	80	0.12
	Crossover studies	4 [18, 21, 28, 29]	174	−1.44cmH₂O	−3.06 to 0.18	83	0.08
	Non-crossover studies	1 [26]	55	0.20cmH₂O	−1.49 to 1.89	0	0.82
Mean inspiratory Pressure	Total	4 [18, 21, 26, 28]	201	0.08cmH₂O	−0.38 to 0.54	60	0.74
	Crossover studies	3 [18, 21, 28]	146	−0.15cmH₂O	−0.48 to 0.18	0	0.38
	Non-crossover studies	1 [26]	55	0.70cmH₂O	0.11 to 1.29	0	0.02

(n) the number of cases, WMD weighted mean difference, CI confidence interval, PCV pressure-controlled ventilation, VCV volume-controlled ventilation, PaO ₂ partial pressure of oxygen, FiO ₂ fraction of inspired oxygen, PaCO ₂ partial pressure of carbon dioxide

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