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Fig. 5 | BMC Anesthesiology

Fig. 5

From: The involvement of protein kinase C-ε in isoflurane induced preconditioning of human embryonic stem cell - derived Nkx2.5+ cardiac progenitor cells

Fig. 5

The role of PKC-ε on 0.5 mM of isoflurane-induced preconditioning of hESCs-derived Nkx2.5+ CPCs under oxidative stress. a εψRACK, a selective PKC-ε activator, induced the effect of preconditioning. * Statistically significant differences with group time control, group Iso + str, group str + εψRACK, and group Iso + str + εψRACK (P < 0.05). b a cell-permeable epsilon PKC V1-2 peptide (εV1-2), a selective PKC-ε inhibitor, abolished the preconditioning effect of isoflurane. * Statistically significant differences with group time control, and group Iso + str (P < 0.05). Each error bar shows the 95 % confidence interval and a diamond denotes the mean value of the death rate of CPCs. Iso + Str = isoflurane plus stress; Str + εV1-2 = stress plus εV1-2; Iso + Str + εV1-2 = isoflurane plus stress εV1-2; Str + εψRACK = stress plus εψRACK; Iso + Str + εψRACK = isoflurane plus stress εψRACK

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BMC Anesthesiology

ISSN: 1471-2253

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