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Fig. 4 | BMC Anesthesiology

Fig. 4

From: The involvement of protein kinase C-ε in isoflurane induced preconditioning of human embryonic stem cell - derived Nkx2.5+ cardiac progenitor cells

Fig. 4

The role of PKC on 0.5 mM of isoflurane-induced preconditioning of hESCs-derived Nkx2.5+ CPCs under oxidative stress. a 4β-phorbol 12-myristate 13-acetate (PMA), an isoform-nonspecific PKC activator, induced the effect of preconditioning. * Statistically significant differences with group time control, group Iso + str, group str + PMA, and group Iso + str + PMA (P < 0.05). b Chelerythrine, an isoform-nonspecific PKC inhibitor, abolished the preconditioning effect of isoflurane. * Statistically significant differences with group time control, and group Iso + str (P < 0.05). Each error bar represents the 95 % confidence interval and a diamond indicates the mean value of the death rate of CPCs. Iso + Str = isoflurane plus stress; Str + Chel = stress plus chelerythrine; Iso + Str + Chel = isoflurane plus stress Chelerythrine; Str + PMA = stress plus PMA; Iso + Str + PMA = isoflurane plus stress PMA

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BMC Anesthesiology

ISSN: 1471-2253

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