Table 3 Overview of the pharmacokinetics of intravenous (iv) paracetamol in cohorts of women as retrieved in literature
From: Paracetamol pharmacokinetics and metabolism in young women
Author | Study characteristics | Clearance (l/h) | Distribution volume (l/kg) | |
|---|---|---|---|---|
Ochs et al. [18] | single iv, 650 mg, young women, age matched study design | |||
Controls (n = 10), 21–30 year, 54 (SE 2.1) kg | 16.8 (SE 0.6) | 0.98 (SE 0.08) | ||
Oral contraceptives (n = 10), 62 (SE 2.5) kg | 22.7 (SE 2.3) | 0.98 (SE 0.06) | ||
Sonne et al. [19] | single iv, 1 000 mg, 2 episodes in each individual | 16.6 | 1.01 | |
3 women 54–56 kg, 29–33 years | ||||
Scaveno et al. [14] | single iv, 650 mg, 30 post-menopausal women | |||
controls (n = 18): 45 (SE 3.9) years, 64.9 (SE 3.3) kg | 16.6 (SE 0.69) | 0.85 (SE 0.04) | ||
conjugated oestrogens (n = 12): 46 (3.4) years, 60.2 (1.7) kg | 16.6 (SE 0.25) | 0.82 (SE 0.05) | ||
Abernethy et al. [9] | single iv, 650 mg, 16 women | |||
controls (n = 8): 23–32 years, 48–66 kg | 13.7 (SD 1.26) | 0.96 (SD 0.08) | ||
oral contraceptives (n = 8): 21–36 years, 48–77 kg | 20.0 (SD 1.68) | 1.04 (SD 0.08) | ||
Wynne et al.[10] | single iv, 500 mg, 42 female/5 male volunteers, .all results pooled | |||
healthy, young: | 25 (SE 1) years, 59 (SE 2) kg | 16.6 (SE 0.71) | 1.00 (SE 0.04) | |
healthy, elderly: | 73 (SE 1) years, 66 (SE 2) kg | 14.6 (SE 0.79) | 1.07 (SE 0.03) | |
frail, elderly: | 82 (SE 2) years, 53 (SE 4) kg | 7.9 (SE 0.32) | 0.81 (SE 0.03) | |
Kulo et al. [16] | single iv, 2 000 mg | |||
28 cases, at delivery | 31.5 (20–42) years, 79 (57–110) kg | 20.3 (11.8–62.8) | 0.72 (0.52–1.56) | |