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Fig. 3 | BMC Anesthesiology

Fig. 3

From: Pretreatment but not subsequent coincubation with midazolam reduces the cytotoxicity of temozolomide in neuroblastoma cells

Fig. 3

Midazolam modifies the toxicity of temozolomide. The IC25, IC50 and IC75 (Panel a, b, and c, respectively) were calculated with nonlinear regression analysis. Whereas pretreatment without subsequent coincubation increased the IC25 and IC50 of temozolomide, pretreatment followed by coincubation with midazolam did not alter the IC25/IC50 of temozolomide. The IC75 was significantly decreased after pretreatment followed by coincubation with midazolam, indicating an additive toxic effect (n = 5; data are expressed as mean ± SD; * = P < 0.05

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BMC Anesthesiology

ISSN: 1471-2253

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